Chemistry:BU-48
From HandWiki
Short description: Chemical compound
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| Formula | C27H33NO4 |
| Molar mass | 435.564 g·mol−1 |
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BU-48 is a drug that is used in scientific research. It is from the oripavine family, related to better-known drugs such as etorphine and buprenorphine.
The parent compound from which BU-48 was derived (with N-methyl rather than methylcyclopropyl on the nitrogen and lacking the aliphatic hydroxyl group) is a powerful μ-opioid agonist 1000 times more potent than morphine,[1] but in contrast BU-48 has only weak analgesic effects and instead acts primarily as a δ-opioid agonist. Its main effects are to produce convulsions,[2] but it may also have antidepressant effects.[3]
See also
References
- ↑ "Narcotic analgesics and antagonists". Annual Review of Pharmacology 11: 241–70. 1971. doi:10.1146/annurev.pa.11.040171.001325. PMID 4948499.
- ↑ "BU48: a novel buprenorphine analog that exhibits delta-opioid-mediated convulsions but not delta-opioid-mediated antinociception in mice". The Journal of Pharmacology and Experimental Therapeutics 294 (3): 1195–200. September 2000. PMID 10945877.
- ↑ "Behavioral effects of delta-opioid receptor agonists: potential antidepressants?". Japanese Journal of Pharmacology 90 (1): 1–6. September 2002. doi:10.1254/jjp.90.1. PMID 12396021.
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