Chemistry:Benazepril
Benazepril, sold under the brand name Lotensin among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.[1] It is a reasonable initial treatment for high blood pressure.[1] It is taken by mouth.[1] Versions are available as the combinations benazepril/hydrochlorothiazide and benazepril/amlodipine.[1]
Common side effects include feeling tired, dizziness, cough, and light-headedness with standing.[1] Serious side effects may include kidney problems, low blood pressure, high blood potassium, and angioedema.[1] Use in pregnancy may harm the baby, while use when breastfeeding may be safe.[2] It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity.[1]
Benazepril was patented in 1981 and came into medical use in 1990. It is available as a generic medication.[1] In 2023, it was the 172nd most commonly prescribed medication in the United States, with more than 2 million prescriptions.[3][4]
Medical uses
Lotensin is indicated for the treatment of hypertension, to lower blood pressure.[5][1]
Side effects
The most common side effects patients experience are a headache or a chronic cough. The chronic cough develops in about 20% of people treated.[6]
Contraindications
Benazepril can harm the fetus.[7]
Dosage forms
It is also available in combination with hydrochlorothiazide, under the brand name Lotensin HCT, and with amlodipine (Lotrel).
Veterinary uses
Under the brand names Fortekor (Novartis)[8] and VetACE (Jurox Animal Health),[9] benazepril is used to treat congestive heart failure in dogs[10][11] and chronic kidney failure in cats and dogs.[12]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 "Benazepril Hydrochloride Monograph for Professionals". American Society of Health-System Pharmacists. https://www.drugs.com/monograph/benazepril-hydrochloride.html.
- ↑ "Benazepril Pregnancy and Breastfeeding Warnings". https://www.drugs.com/pregnancy/benazepril.html.
- ↑ "Top 300 of 2023". https://clincalc.com/DrugStats/Top300Drugs.aspx.
- ↑ "Benazepril Drug Usage Statistics, United States, 2013 - 2023". https://clincalc.com/DrugStats/Drugs/Benazepril.
- ↑ Cite error: Invalid
<ref>tag; no text was provided for refs namedLotensin FDA label - ↑ "Cough and Angioedema From Angiotensin-Converting Enzyme Inhibitors: New Insights Into Mechanisms and Management". Medscape. April 2004. http://www.medscape.com/viewarticle/484537_2.
- ↑ "Lotensin package insert". 2011. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020033s040lbl.pdf.
- ↑ "Fortekor Flavor Tabs (5 mg) for Animal Use (Canada)" (in en). https://www.drugs.com/vet/fortekor-flavor-tabs-5-mg-can.html.
- ↑ "VetACE® - Jurox" (in en-AU). https://www.jurox.com.au/product/vetace/.
- ↑ "Pharmacokinetics of the active metabolite of benazepril, benazeprilat, and inhibition of plasma angiotensin-converting enzyme activity after single and repeated administrations to dogs". American Journal of Veterinary Research 56 (12): 1620–1628. December 1995. doi:10.2460/ajvr.1995.56.12.1620. PMID 8599524.
- ↑ "Efficacy of benazepril hydrochloride to delay the progression of occult dilated cardiomyopathy in Doberman Pinschers". Journal of Veterinary Internal Medicine 23 (5): 977–983. 2009. doi:10.1111/j.1939-1676.2009.0346.x. PMID 19572914.
- ↑ "Fortekor Flavor Tabs (5 mg) (Canada) for Animal Use". https://www.drugs.com/vet/fortekor-flavor-tabs-5-mg-can.html.
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