Chemistry:Zofenopril
From HandWiki
Short description: Antihypertensive drug of the ACE inhibitor class
 | |
| Clinical data | |
|---|---|
| Trade names | Zocardis (Russia ) |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
| ATC code | |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C22H23NO4S2 |
| Molar mass | 429.55 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  (what is this?) (verify) | |
Zofenopril (INN) is a medication that protects the heart and helps reduce high blood pressure. It is an angiotensin-converting enzyme (ACE) inhibitor.[1]
In small studies, zofenopril appeared significantly more effective in reducing hypertension than two older antihypertensive drugs, atenolol and enalapril, and was associated with fewer adverse effects.[2][3]
Zofenopril is a prodrug with zofenoprilat as the active metabolite.[4]
It was patented in 1978 and approved for medical use in 2000.[5]
References
- ↑ "Defining the role of zofenopril in the management of hypertension and ischemic heart disorders". American Journal of Cardiovascular Drugs 7 (1): 17–24. 2007. doi:10.2165/00129784-200707010-00002. PMID 17355163.
- ↑ "Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension". Blood Pressure. Supplement 2: 25–30. October 2007. doi:10.1080/08038020701561745. PMID 18046976.
- ↑ "An evaluation of the initial and long-term antihypertensive efficacy of zofenopril compared with enalapril in mild to moderate hypertension". Blood Pressure. Supplement 2: 13–18. October 2007. doi:10.1080/08038020701561703. PMID 18046974.
- ↑ "Preclinical Profile of Zofenopril: An Angiotensin Converting Enzyme Inhibitor with Peculiar Cardioprotective Properties". Cardiovascular Drug Reviews 17 (2): 115–133. 1999. doi:10.1111/j.1527-3466.1999.tb00008.x.
- ↑ (in en) Analogue-based Drug Discovery. John Wiley & Sons. 2006. p. 467. ISBN 978-3-527-60749-5. https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA467.
 |  |
