Chemistry:Saralasin
From HandWiki
![]() | |
Names | |
---|---|
IUPAC name
(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid
| |
Other names
Sar-Arg-Val-Tyr-Val-His-Pro-Ala
| |
Identifiers | |
3D model (JSmol)
|
|
ChEMBL | |
ChemSpider | |
PubChem CID
|
|
UNII | |
| |
| |
Properties | |
C42H65N13O10 | |
Molar mass | 912.05 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
![]() ![]() ![]() | |
Infobox references | |
Tracking categories (test):
Saralasin is a competitive angiotensin II receptor antagonist with partial agonistic activity. The aminopeptide sequence for saralasin differs from angiotensin II at three sites:
- At position 1, sarcosine replaces aspartic acid, thereby increasing the affinity for vascular smooth muscle AT II receptors and making sara resistant to degradation by aminopeptidases.[1]
- At position 5, isoleucine is replaced by valine
- At position 8, phenylalanine is replaced by alanine which leads to a smaller stimulatory effect. Saralasin was used to distinguish renovascular hypertension from essential hypertension before its discontinuation in January 1984 because of many false-positive and false-negative reports.[2]
References
External links
- Saralasin at the US National Library of Medicine Medical Subject Headings (MeSH)
- "Intracerebroventricular administration of the angiotensin II receptor antagonist saralasin reduces respiratory rate and tidal volume variability in freely moving Wistar rats.". Psychoneuroendocrinology 29 (1): 107–12. 2004. doi:10.1016/S0306-4530(02)00147-6. PMID 14575733.
- "Saralasin, a nonspecific angiotensin II receptor antagonist, attenuates oxidative stress and tissue injury in cerulein-induced acute pancreatitis.". Pancreas 26 (3): 224–9. 2003. doi:10.1097/00006676-200304000-00003. PMID 12657946.
- "Differential effects of saralasin and ramiprilat, the inhibitors of renin-angiotensin system, on cerulein-induced acute pancreatitis.". Regul Pept 111 (1–3): 47–53. 2003. doi:10.1016/S0167-0115(02)00226-4. PMID 12609748.
![]() | Original source: https://en.wikipedia.org/wiki/Saralasin.
Read more |