Chemistry:Derrubone
From HandWiki
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| Names | |
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| IUPAC name
5,7-Dihydroxy-6-(3-methylbut-2-en-1-yl)-3′,4′-[methylenebis(oxy)]isoflavone
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| Systematic IUPAC name
3-(2H-1,3-Benzodioxol-5-yl)-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-1-benzopyran-4-one | |
| Other names
5,7-Dihydroxy-3',4'-methylenedioxy-6-prenylisoflavone
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| Identifiers | |
3D model (JSmol)
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PubChem CID
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| Properties | |
| C21H18O6 | |
| Molar mass | 366.369 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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| Infobox references | |
Derrubone is a prenylated isoflavone, a type of flavonoid. It was originally isolated from the Indian tree Derris robusta.[1] Recent research indicates that it acts as an inhibitor of Hsp90 to its function as a chaperone protein.[2]
References
- ↑ "Natural occurrence of 3-aryl-4-hydroxycoumarins. Part I. Phytochemical examination of Derris robusta(roxb.) benth.". J. Chem. Soc. C 3 (3): 365–74. 1969. doi:10.1039/J39690000365. http://www.rsc.org/publishing/journals/J3/article.asp?doi=J39690000365.
- ↑ "Derrubone, an inhibitor of the Hsp90 protein folding machinery". J. Nat. Prod. 70 (12): 2014–8. December 2007. doi:10.1021/np070190s. PMID 18020309.
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