Chemistry:Daidzin
From HandWiki
Daidzin is a natural organic compound in the class of phytochemicals known as isoflavones. Daidzin can be found in Chinese plant kudzu (Pueraria lobata, Fabaceae) and from soybean leaves.[1]
Daidzin is the 7-O-glucoside of daidzein.
Daidzin has shown the potential for the treatment of alcohol dependency (antidipsotropic) based on animal models.[2][3]
List of plants that contain the chemical
Biosynthesis
Daidzin is an isoflavone, which are isomers of the large group of plant metabolites called flavones. Its biosynthesis begins in a phenylpropanoid metabolic pathway from the amino acid phenylalanine. After several steps, the intermediate daidzein is formed. The enzyme isoflavone 7-O-glucosyltransferase then adds a glycosyl group by transfer from UDP-glucose.[8][9]
Notes and references
- ↑ Osman, S; Fett, W (1983). "Isoflavone glucoside stress metabolites of soybean leaves". Phytochemistry 22 (9): 1921. doi:10.1016/0031-9422(83)80013-2. Bibcode: 1983PChem..22.1921O.
- ↑ Rezvani, A; Overstreet, David H; Perfumi, Marina; Massi, Maurizio (2003). "Plant derivatives in the treatment of alcohol dependency". Pharmacology Biochemistry and Behavior 75 (3): 593–606. doi:10.1016/S0091-3057(03)00124-2. PMID 12895677.
- ↑ Keung WM; Vallee BL (February 1998). "Kudzu root: an ancient Chinese source of modern antidipsotropic agents". Phytochemistry 47 (4): 499–506. doi:10.1016/S0031-9422(97)00723-1. PMID 9461670. Bibcode: 1998PChem..47..499K.
- ↑ Pongkitwitoon B et al. (December 2009). "Enzyme-Linked Immunosorbent Assay for Total Isoflavonoids in Pueraria candollei Using Anti-Puerarin and Anti-Daidzin Polyclonal Antibodies". Planta Medica 76 (8): 831–6. doi:10.1055/s-0029-1240725. PMID 20033865.
- ↑ Jin WS; Tan YY; Chen YG; Wang Y (January 2003). "[Determination of puerarin, daidzin and daidzein in root of Pueraria lobata of different origin by HPLC]" (in Chinese). Zhongguo Zhong Yao Za Zhi 28 (1): 49–51. PMID 15015267.
- ↑ Zhou HY; Wang JH; Yan FY (May 2007). "[Separation and determination of puerarin, daidzin and daidzein in stems and leaves of Pueraria thomsonii by RP-HPLC]" (in Chinese). Zhongguo Zhong Yao Za Zhi 32 (10): 937–9. PMID 17655152.
- ↑ Park EK; Shin J; Bae EA; Lee YC; Kim DH (December 2006). "Intestinal bacteria activate estrogenic effect of main constituents puerarin and daidzin of Pueraria thunbergiana". Biological & Pharmaceutical Bulletin 29 (12): 2432–5. doi:10.1248/bpb.29.2432. PMID 17142977.
- ↑ Ververidis Filippos, F; Trantas Emmanouil; Douglas Carl; Vollmer Guenter; Kretzschmar Georg; Panopoulos Nickolas (October 2007). "Biotechnology of flavonoids and other phenylpropanoid-derived natural products. Part I: Chemical diversity, impacts on plant biology and human health". Biotechnology Journal 2 (10): 1214–34. doi:10.1002/biot.200700084. PMID 17935117.
- ↑ "UDP-glucose:isoflavone 7-O-glucosyltransferase from roots of chick pea (Cicer arietinum L.)". Arch. Biochem. Biophys. 212 (1): 98–104. 1981. doi:10.1016/0003-9861(81)90347-7. PMID 6458246.
See also
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