Chemistry:Modimelanotide
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Short description: Chemical compound
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| Other names | Acetylhexa-L-lysyl-α-MSH |
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| Formula | C113H181N33O25S |
| Molar mass | 2433.96 g·mol−1 |
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Modimelanotide (INN) (code names AP-214, ABT-719, ZP-1480) is a melanocortinergic peptide drug derived from α-melanocyte-stimulating hormone (α-MSH) which was under development by, at different times, Action Pharma, Abbott Laboratories, AbbVie, and Zealand for the treatment of acute kidney injury.[1][2] It acts as a non-selective melanocortin receptor agonist, with IC50 values of 2.9 nM, 1.9 nM, 3.7 nM, and 110 nM at the MC1, MC3, MC4, and MC5 receptors.[3] Modimelanotide failed clinical trials for acute kidney injury despite showing efficacy in animal models,[4][5] and development was not further pursued.[1][2]
See also
- Afamelanotide
- BMS-470,539
- Bremelanotide
- Melanotan II
- PF-00446687
- Setmelanotide
References
- ↑ 1.0 1.1 "Designing drugs that combat kidney damage". Expert Opinion on Drug Discovery 10 (5): 541–56. May 2015. doi:10.1517/17460441.2015.1033394. PMID 25840605.
- ↑ 2.0 2.1 "ACTH: The forgotten therapy". Seminars in Immunology 27 (3): 216–26. May 2015. doi:10.1016/j.smim.2015.02.003. PMID 25726511.
- ↑ "Renal-Urologic drugs". Drug Data Reports (Prous Science) 29 (1): 42. 2007. ISSN 0379-4121. https://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summary_pr?p_JournalId=1&p_RefId=3563&p_IsPs=Y.
- ↑ "AP214, an analogue of alpha-melanocyte-stimulating hormone, ameliorates sepsis-induced acute kidney injury and mortality". Kidney International 73 (11): 1266–74. June 2008. doi:10.1038/ki.2008.97. PMID 18354376.
- ↑ "Alpha-melanocyte stimulating hormone analogue AP214 protects against ischemia induced acute kidney injury in a porcine surgical model". The Journal of Urology 183 (4): 1625–9. April 2010. doi:10.1016/j.juro.2009.12.007. PMID 20172543.
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