Chemistry:Monosodium citrate

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Monosodium citrate
Monosodium citrate.png
Monosodium citrate.jpg
Names
Other names
sodium dihydrogen 2-hydroxypropane-1,2,3-tricarboxylate
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
EC Number
  • 242-734-6
RTECS number
  • GE9750000
UNII
Properties
C6H7NaO7
Molar mass 214.105 g·mol−1
Appearance white powder
hygroscopic
Odor odorless
Melting point 212 °C (414 °F; 485 K)
Boiling point 309.6 °C (589.3 °F; 582.8 K)
soluble
Solubility negligible in ethanol
Acidity (pKa) 3.50–3.80
Structure[1]
Monoclinic
P21/a (No. 4)
4
Hazards
Safety data sheet Carl Roth
Lethal dose or concentration (LD, LC):
5400 mg/kg (mouse, oral) >2000 mg/kg (rat, dermal)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Monosodium citrate, more correctly, sodium dihydrogen citrate (Latin: natrium citricum acidulatum), is an acid salt of citric acid. Disodium citrate and trisodium citrate are also known. It can be prepared by partial neutralisation of citric acid[2] with an aqueous solution of sodium bicarbonate or carbonate. It has a slightly acidic taste.[2]

NaHCO3 + C6H8O7 → NaC6H7O7 + CO2 + H2O
Na2CO3 + 2C6H8O7 → 2NaC6H7O7 + CO2 + H2O

It is highly soluble in water and practically insoluble in ethanol.[2] Monosodium citrate is used as an anticoagulant in donated blood.[3] It is used as an alkalinizing agent to prevent kidney stone disease.[4] The crystals form as nearly perfect cubes.[5]

References

  1. Glusker, Jenny P.; van der Helm, D.; Love, Warner E.; Dornberg, Marilyn L.; Patterson, A. L. (June 1960). "The State of Ionization of Crystalline Sodium Dihydrogen Citrate1" (in en). Journal of the American Chemical Society 82 (11): 2964–2965. doi:10.1021/ja01496a071. ISSN 0002-7863. https://pubs.acs.org/doi/10.1021/ja01496a071. Retrieved 22 July 2022. 
  2. 2.0 2.1 2.2 "Monosodium Citrate - Jungbunzlauer". https://www.jungbunzlauer.com/en/products/special-salts/monosodium-citrate.html. 
  3. Clinical Hematology: Theory and Procedures, Mary Louise Turgeon
  4. PubChem. "Monosodium citrate" (in en). https://pubchem.ncbi.nlm.nih.gov/compound/23666341. 
  5. Hitchcock, David I. (March 1946). "Sodium Hydrogen Citrates" (in en). Journal of the American Chemical Society 68 (3): 524–525. doi:10.1021/ja01207a507. ISSN 0002-7863. PMID 21015754. https://pubs.acs.org/doi/10.1021/ja01207a507. Retrieved 22 July 2022.