Chemistry:Myriocin
Myriocin, also known as antibiotic ISP-1 and thermozymocidin, is a non-proteinogenic amino acid derived from the entomopathogenic fungus, Isaria sinclairii.[1]
Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[1] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids.
Myriocin was shown to inhibit the proliferation of an IL-2-dependent mouse cytotoxic T cell line.[2]
Myriocin possesses immunosuppressant activity. It is reported to be 10- to 100-fold more potent than ciclosporin.[citation needed]
The multiple sclerosis drug fingolimod was derived from myriocin by using structure–activity relationship studies to determine the parts of the molecule important to its activity.[citation needed]
References
- ↑ 1.0 1.1 "Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin". Biochem. Biophys. Res. Commun. 211 (2): 396–403. 1995. doi:10.1006/bbrc.1995.1827. PMID 7794249.
- ↑ Lee, Y.-S.; Choi, K.-M.; Choi, M.-H.; Ji, S.-Y.; Lee, S.; Sin, D.-M.; Oh, K.-W.; Lee, Y.-M. et al. (2011). "Serine palmitoyltransferase inhibitor myriocin induces growth inhibition of B16F10 melanoma cells through G(2) /M phase arrest". Cell Proliferation 44 (4): 320–329. doi:10.1111/j.1365-2184.2011.00761.x. ISSN 1365-2184. PMID 21645154. PMC 6496407. https://pubmed.ncbi.nlm.nih.gov/21645154.
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