Chemistry:Nebracetam
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Short description: Chemical compound
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| Formula | C12H16N2O |
| Molar mass | 204.273 g·mol−1 |
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| Chirality | Racemic mixture |
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Nebracetam is an investigational drug of the racetam family that is a M1 acetylcholine receptor agonist in rats.[1] Based on a human leukemic T cell experiment in 1991, it is believed to act as an agonist for human M1-muscarinic receptors.[2] It is also believed to act as a nootropic, like many other racetam drugs.[3] A chemoenzymatic method of synthesis was reported in 2008.[4] (As of 2023), human trials have not yet been conducted.
See also
- Piracetam
- Aniracetam
- Racetam
References
- ↑ "Effects of delayed treatment with nebracetam on neurotransmitters in brain regions after microsphere embolism in rats". British Journal of Pharmacology 121 (3): 477–84. June 1997. doi:10.1038/sj.bjp.0701161. PMID 9179389.
- ↑ Kitamura, Y.; Kaneda, T.; Nomura, Y. (January 1991). "Effects of nebracetam (WEB 1881 FU), a novel nootropic, as a M1-muscarinic agonist". Japanese Journal of Pharmacology 55 (1): 177–180. doi:10.1254/jjp.55.177. ISSN 0021-5198. PMID 2041225. https://pubmed.ncbi.nlm.nih.gov/2041225/.
- ↑ Gabryel, B.; Pudełko, A.; Trzeciak, H. I.; Cieślik, P. (2000). "Effect of nebracetam on content of high-energy phosphates and morphometry of rat astrocytes in vitro. Comparison with piracetam". Acta Poloniae Pharmaceutica 57 (4): 289–298. ISSN 0001-6837. PMID 11126618. https://pubmed.ncbi.nlm.nih.gov/11126618/.
- ↑ Yamashita, Sho; Mase, Nobuyuki; Takabe, Kunihiko (2008-09-22). "Chemoenzymatic total synthesis and determination of the absolute configuration of (S)-nebracetam". Tetrahedron: Asymmetry 19 (18): 2115–2118. doi:10.1016/j.tetasy.2008.09.004. ISSN 0957-4166. https://www.sciencedirect.com/science/article/pii/S0957416608006162.
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