Chemistry:Poly ICLC
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Poly ICLC is an immunostimulant. It is polyinosinic-polycytidylic acid (poly I:C) mixed with the stabilizers carboxymethylcellulose and polylysine.[1] It is under trial for use in cancer.[2]
Poly I:C is a ligand for toll like receptor-3, which usually triggers on the structurally similar double-stranded RNA present in some viruses.[1]
References
- ↑ 1.0 1.1 "Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models". Journal of Translational Medicine 5: 10. 2007. doi:10.1186/1479-5876-5-10. PMID 17295916.
- ↑ "Intervention Dynamic Trial Listing Page" (in en). 13 June 2017. https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/poly-iclc.
External links
- National Cancer Institute: poly ICLC
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