Chemistry:Thymopentin
From HandWiki
Thymopentin is a thymic polypeptide derivative which interacts with T cells and acts as an immunostimulant.[1][2][3][4] As such, it was used in several clinical studies in the early years of the AIDS pandemic (from 1983 to 1985). Thymopentin helped to improve immunological condition in some patients for a brief time under specific treatments.[5][6][7] It has also been investigated more recently for applications in the treatment of rheumatoid arthritis,[8] and lung cancer.[9]
See also
References
- ↑ "Molecular analysis of thymopentin binding to HLA-DR molecules". PLOS ONE 2 (12). December 2007. doi:10.1371/journal.pone.0001348. PMID 18159232. Bibcode: 2007PLoSO...2.1348L.
- ↑ "Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells". Cell Biology International 32 (10): 1265–1271. October 2008. doi:10.1016/j.cellbi.2008.07.011. PMID 18692582.
- ↑ "Thymopentin plays a key role in restoring the function of macrophages to alleviate the sepsis process". International Immunopharmacology 126. January 2024. doi:10.1016/j.intimp.2023.111295. PMID 38048668.
- ↑ "Effectiveness and safety of thymopentin for infection prophylaxis in peritoneal dialysis patients: a retrospective study". BMC Nephrology 26 (1). September 2025. doi:10.1186/s12882-025-04465-w. PMID 41023915.
- ↑ "Stimulation of cellular function by thymopentin (TP-5) in three AIDS patients". Lancet 2 (8352): 735–736. September 1983. doi:10.1016/S0140-6736(83)92271-7. PMID 6193382.
- ↑ "Preliminary results on clinical and immunological effects of thymopentin in AIDS". International Journal of Clinical Pharmacology Research 4 (6): 459–463. 1984. PMID 6398315.
- ↑ "Thymopentin treatment in AIDS and pre-AIDS patients". Survey of Immunologic Research 4 (Suppl 1): 58–62. 1985. doi:10.1007/BF02919057. PMID 3898293.
- ↑ "Thymopentin treatment of rheumatoid arthritis". Arzneimittel-Forschung 44 (10): 1145–1149. October 1994. PMID 7818590.
- ↑ "Mechanism and clinical application of thymosin in the treatment of lung cancer". Frontiers in Immunology 14. 2023. doi:10.3389/fimmu.2023.1237978. PMID 37701432.
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