Chemistry:Pyrazofurin
From HandWiki
Short description: Chemical compound
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| Trade names | Pyrazofurin |
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| Formula | C9H13N3O6 |
| Molar mass | 259.22 g·mol−1 |
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Pyrazofurin (pyrazomycin) is a natural product found in Streptomyces candidus, which is a nucleoside analogue related to ribavirin. It has antibiotic, antiviral and anti-cancer properties but was not successful in human clinical trials due to severe side effects. Nevertheless, it continues to be the subject of ongoing research as a potential drug of last resort, or a template for improved synthetic derivatives.[1][2][3][4][5][6][7][8]
See also
- Acadesine
- EICAR (antiviral)
- Sangivamycin
References
- ↑ "Antiviral efficacy of pyrazofurin against selected RNA viruses". Antiviral Research 2 (6): 331–7. December 1982. doi:10.1016/0166-3542(82)90002-x. PMID 6299188.
- ↑ "The C-nucleoside antibiotics". Fortschritte der Chemie Organischer Naturstoffe. Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products 44: 243–99. 1983. doi:10.1007/978-3-7091-8714-2_4. ISBN 978-3-7091-8716-6. PMID 6360831.
- ↑ "The chemistry and biochemistry of C-nucleosides and C-arylglycosides". Progress in Medicinal Chemistry 22: 1–65. 1985. doi:10.1016/s0079-6468(08)70228-5. PMID 3915364.
- ↑ "Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives". Medicinal Research Reviews 29 (4): 611–45. July 2009. doi:10.1002/med.20153. PMID 19260077.
- ↑ "Curious (Old and New) Antiviral Nucleoside Analogues with Intriguing Therapeutic Potential". Current Medicinal Chemistry 22 (34): 3866–80. 2015. doi:10.2174/0929867322666150625094705. PMID 26112146.
- ↑ "C-Nucleosides To Be Revisited". Journal of Medicinal Chemistry 59 (6): 2301–11. March 2016. doi:10.1021/acs.jmedchem.5b01157. PMID 26513594.
- ↑ "New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections". Chemistry: An Asian Journal 14 (22): 3962–3968. November 2019. doi:10.1002/asia.201900841. PMID 31389664.
- ↑ "Identification of the C-Glycoside Synthases during Biosynthesis of the Pyrazole-C-Nucleosides Formycin and Pyrazofurin". Angewandte Chemie 58 (46): 16512–16516. November 2019. doi:10.1002/anie.201910356. PMID 31518483.
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