Chemistry:Ricobendazole
From HandWiki
Ricobendazole, also known as albendazole S-oxide, is a broad-spectrum benzimidazole anthelmintic. Its main use is for protecting livestock against nematode parasites.[1] Ricobendazole is the active sulfoxide metabolite of albendazole.[2]
Like mebendazole, ricobendazole inhibits tubulin polymerization.
Metabolic product of albendazole
Ricobendazole is produced in many species and in human liver when albendazole undergoes first-pass metabolism by the enzymes albendazole monooxygenase (sulfoxide-forming) (a cytochrome P450 oxidase) or albendazole monooxygenase (a flavin-containing monooxygenase.[3]
References
- ↑ Junquera, P (26 July 2015). "Ricobendazole = Albendazole Sulfoxide for Veterinary Use on Cattle, Sheep, Goats, Pig Poultry, Dogs and Cats against roundworms, tapeworms and liver flukes". http://parasitipedia.net/index.php?option=com_content&view=article&id=2518&Itemid=2791.
- ↑ Stuchlíková, Lucie Raisová; Matoušková, Petra; Vokřál, Ivan; Lamka, Jiří; Szotáková, Barbora; Sečkařová, Anna; Dimunová, Diana; Nguyen, Linh Thuy et al. (2018). "Metabolism of albendazole, ricobendazole and flubendazole in Haemonchus contortus adults: Sex differences, resistance-related differences and the identification of new metabolites". International Journal for Parasitology: Drugs and Drug Resistance 8 (1): 50–58. doi:10.1016/j.ijpddr.2018.01.005. PMID 29414106.
- ↑ Rawden, Helen C.; Kokwaro, Gilbert O.; Ward, Stephen A.; Edwards, Geoffrey (2000). "Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes". British Journal of Clinical Pharmacology 49 (4): 313–322. doi:10.1046/j.1365-2125.2000.00170.x. PMID 10759686.
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