Chemistry:Tribendimidine
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Short description: Chemical compound
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| Formula | C28H32N6 |
| Molar mass | 452.606 g·mol−1 |
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Tribendimidine is a broad-spectrum anthelmintic agent developed in China , at the National Institute of Parasitic Diseases in Shanghai. It is a derivative of amidantel.[1]
In clinical trials, it was highly effective in treating ankylostomiasis, ascariasis and enterobiasis.[2] It is also effective against clonorchiasis.[3] However, animal studies suggest it is ineffective in treating Schistosoma mansoni or Fasciola hepatica disease.[1] The drug has also performed well in trials against opisthorchiasis, curing about 70% of cases.[4]
Tribendimidine is manufactured by Shandong Xinhua Pharmaceutical Company Limited in Zibo, Shandong, China . It was approved by the China Food and Drug Administration in 2007.[citation needed]
References
- ↑ 1.0 1.1 "Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini". Antimicrobial Agents and Chemotherapy 51 (3): 1096–1098. March 2007. doi:10.1128/AAC.01366-06. PMID 17194822. Free full text.
- ↑ "Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China". Acta Tropica 94 (1): 1–14. April 2005. doi:10.1016/j.actatropica.2005.01.013. PMID 15777691.
- ↑ "Development and application of anthelminthic drugs in China". Acta Tropica 200: 105181. December 2019. doi:10.1016/j.actatropica.2019.105181. PMID 31542370.
- ↑ "New drug shows promise against Asian liver fluke". Reuters. 2010-11-24. https://www.reuters.com/article/us-liver-fluke-drugs-idUSTRE6AO00520101125.
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