Chemistry:Stibophen
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Short description: Chemical compound
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Formula | C12H4Na5O16S4Sb |
Molar mass | 769.10 g·mol−1 |
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Stibophen is an anthelmintic originally developed by Bayer that is used as a treatment for schistosomiasis[1] by intramuscular injection. It is classified as a trivalent antimony compound. Brand names include Fouadin/Fuadin (named in honor of Fuad I of Egypt, who had enthusiastically supported its research and development).[2][3]
Mechanism of action
Stibophen inhibits the enzyme phosphofructokinase, which the worms need for glycolysis,[4] at least partly by binding to the sulfhydryl (–SH) group of the enzyme.[5] Inhibiting glycolysis paralyzes the worms, which lose their hold on the wall of mesenteric veins and undergo hepatic shift, die, and are phagocytosed by liver cells.[citation needed]
References
- ↑ "Treatment of vesical schistosomiasis with stibophen". The American Journal of Tropical Medicine and Hygiene 4 (6): 1049–56. November 1955. doi:10.4269/ajtmh.1955.4.1049. PMID 13268811.
- ↑ "Treatment of Bilharziasis With a New Compound 'Fouadin.'". Lancet 215 (5553): 234–35. February 1930. doi:10.1016/S0140-6736(00)87344-4.
- ↑ "The Specific Effect of 'Fouadin' (Fuadin) on Granuloma Inguinale: Preliminary Report". JAMA 100 (21): 1671–76. May 1933. doi:10.1001/jama.1933.02740210019007.
- ↑ "The relationship between inhibition of phosphofructokinase activity and the mode of action of trivalent organic antimonials on Schistosoma mansoni". British Journal of Pharmacology and Chemotherapy 12 (2): 159–65. June 1957. doi:10.1111/j.1476-5381.1957.tb00114.x. PMID 13446367.
- ↑ "Purification, kinetics and inhibition by antimonials of recombinant phosphofructokinase from Schistosoma mansoni". Molecular and Biochemical Parasitology 81 (2): 171–8. October 1996. doi:10.1016/0166-6851(96)02702-8. PMID 8898332.
Original source: https://en.wikipedia.org/wiki/Stibophen.
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