Chemistry:TGOT

From HandWiki

TGOT, also known as [Thr4,Gly7]-oxytocin, is a synthetic peptide oxytocin receptor agonist which is widely used in scientific research.[1][2] It is a potent and selective agonist of the oxytocin receptor.[1][2] The drug has very high affinity and selectivity for the oxytocin receptor in rodents but the same is not true in humans, and hence it shows no advantage over oxytocin in humans.[1][3][4]

TGOT has been found to partially reverse the adverse behavioral changes caused by social isolation in rodents, for instance social avoidance and aggression.[5][6] It shows partially dissociable effects from those of oxytocin in rodents, which may be related to comparative selectivity against vasopressin receptors.[7]

TGOT was first described in the scientific literature by 1977.[8] TGOT, or [Thr4,Gly7]-oxytocin, should not be confused with triglycyl-oxytocin, which is also known by the acronym TGOT but is a different peptide oxytocin analogue that is far less-known in comparison.[9][10]

See also

References

  1. ↑ 1.0 1.1 1.2 "The Oxytocin Receptor: From Intracellular Signaling to Behavior". Physiological Reviews 98 (3): 1805–1908. July 2018. doi:10.1152/physrev.00031.2017. PMID 29897293. 
  2. ↑ 2.0 2.1 "Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics". Journal of Neuroendocrinology 24 (4): 609–628. April 2012. doi:10.1111/j.1365-2826.2012.02303.x. PMID 22375852. 
  3. ↑ "Molecular Basis of Oxytocin Receptor Signalling in the Brain: What We Know and What We Need to Know". Current Topics in Behavioral Neurosciences 35: 3–29. 2018. doi:10.1007/7854_2017_6. ISBN 978-3-319-63738-9. PMID 28812263. 
  4. ↑ "Selective and potent agonists and antagonists for investigating the role of mouse oxytocin receptors". The Journal of Pharmacology and Experimental Therapeutics 346 (2): 318–327. August 2013. doi:10.1124/jpet.113.202994. PMID 23723434. 
  5. ↑ "Impact of social isolation on the oxytocinergic system: A systematic review and meta-analysis of rodent data". Neuroscience and Biobehavioral Reviews 134. March 2022. doi:10.1016/j.neubiorev.2022.104549. PMID 35074312. 
  6. ↑ "Oxytocin and vasopressin inhibit hyper-aggressive behaviour in socially isolated mice". Neuropharmacology 156. September 2019. doi:10.1016/j.neuropharm.2019.03.016. PMID 30885607. https://figshare.com/articles/journal_contribution/20716024. 
  7. ↑ "Adolescent exposure to oxytocin, but not the selective oxytocin receptor agonist TGOT, increases social behavior and plasma oxytocin in adulthood". Hormones and Behavior 65 (5): 488–496. May 2014. doi:10.1016/j.yhbeh.2014.03.002. PMID 24631584. 
  8. ↑ "Synthesis and some pharmacological properties of [4-threonine, 7-glycine]oxytocin, [1-(L-2-hydroxy-3-mercaptopropanoic acid), 4-threonine, 7-glycine]oxytocin (hydroxy[Thr4, Gly7]oxytocin), and [7-Glycine]oxytocin, peptides with high oxytocic-antidiuretic selectivity". Journal of Medicinal Chemistry 20 (1): 120–123. January 1977. doi:10.1021/jm00211a025. PMID 833810. 
  9. ↑ "Activation and clearance of a hormonogen, triglycyl-oxytocin, in the conscious dog". Acta Endocrinologica (Copenh) 99 (2): 211–217. February 1982. doi:10.1530/acta.0.0990211. PMID 7058681. 
  10. ↑ PubChem. "oxytocin, tri-Gly-". https://pubchem.ncbi.nlm.nih.gov/compound/3082106. 



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