Chemistry:Temarotene
From HandWiki
Temarotene is a synthetic arotinoid compound with the molecular formula C
23H
28.[1][2] The compound is an orally active drug known for its immunosuppressive and immunostimulatory activities. Temarotene was also studied as a chemopreventive agent.
Synthesis
Synthesis of arotinoid acid and temarotene starts with mixed (Z)-1,2-bis(organylchalcogene)-1-alkene as a precursor.[3]
Uses
Temarotene functions as an orally administered immunomodulator, exhibiting both immunosuppressive and immunostimulatory properties. Studies demonstrate its ability to regulate ornithine decarboxylase (ODC) gene expression in vitro, a mechanism linked to its effects on cellular differentiation and immune response. Temarotene is also used in the study of lichen planus.[4]
References
- ↑ Hong, Waun Ki; Lotan, Reuben (24 July 2020) (in en). Retinoids in Oncology. CRC Press. p. 92. ISBN 978-1-000-14822-0. https://books.google.com/books?id=NijxDwAAQBAJ&dq=Temarotene&pg=PA91. Retrieved 13 April 2025.
- ↑ "NCATS Inxight Drugs — TEMAROTENE" (in en). drugs.ncats.io. https://drugs.ncats.io/drug/A28G39IJ7K.
- ↑ Guerrero, Palimécio G.; de Oliveira, Paulo R.; Baroni, Adriano C. M.; Marques, Francisco A.; Labes, Ricardo; Hurtado, Gabriela R.; Dabdoub, Miguel J. (26 September 2012). "Synthesis of arotinoid acid and temarotene using mixed (Z)-1,2-bis(organylchalcogene)-1-alkene as precursor". Tetrahedron Letters 53 (39): 5302–5305. doi:10.1016/j.tetlet.2012.07.092. ISSN 0040-4039.
- ↑ "Temarotene | TargetMol" (in en). targetmol.com. https://www.targetmol.com/compound/temarotene.
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