Chemistry:Vasicine
| |
| Names | |
|---|---|
| IUPAC name
1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazolin-3-ol
| |
| Other names
Peganine
| |
| Identifiers | |
3D model (JSmol)
|
|
PubChem CID
|
|
| UNII | |
| |
| Properties | |
| C11H12N2O | |
| Molar mass | 188.230 g·mol−1 |
| Melting point | 210 °C (410 °F; 483 K) |
| Solubility in acetone, alcohol, chloroform | Soluble |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Vasicine (peganine) is a quinazoline alkaloid. It is found in Justicia adhatoda, after which it is named. It is additionally found in Peganum harmala.[1]
Vasicine has been compared to theophylline both in vitro and in vivo.[2] It has also been studied in combination with the related alkaloid vasicinone. Both the alkaloids in combination (1:1) showed pronounced bronchodilatory activity in vivo and in vitro.[3] Both alkaloids are also respiratory stimulants.[3] Vasicine has a cardiac–depressant effect, while vasicinone is a weak cardiac stimulant; the effect can be normalized by combining the alkaloids.[3][4] Vasicine is reported to have a uterine stimulant effect.[4]
Bromhexine, a synthetic compound imitating the molecular shape of vasicine[citation needed], is a common ingredient of cough medicine for its mucolytic properties; it increases the production of serous mucus in the respiratory tract which makes the phlegm thinner and less viscous, which allows the cilia to more easily transport the phlegm out of the lungs.
References
- ↑ "Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids". Pharmacogn Rev 7 (14): 199–212. July 2013. doi:10.4103/0973-7847.120524. PMID 24347928.
- ↑ Nepali, Kunal; Sharma, Sahil; Ojha, Ritu; Dhar, Kanaya Lal (2012). "Vasicine and structurally related quinazolines". Medicinal Chemistry Research 22 (1): 1–15. doi:10.1007/s00044-012-0002-5. ISSN 1054-2523.
- ↑ 3.0 3.1 3.2 Avula, B. (2008). "Quantitative determination of vasicine and vasicinone in Adhatoda vasica by high performance capillary electrophoresis". Die Pharmazie 63 (1): 20–22. doi:10.1691/ph.2008.7175. PMID 18271297. http://docserver.ingentaconnect.com/deliver/connect/govi/00317144/v63n1/s4.pdf?expires=1388798104&id=76777466&titleid=75007325.
- ↑ 4.0 4.1 Rajani, M; Soni, S; Anandjiwala, Sheetal; Patel, G (2008). "Validation of different methods of preparation of Adhatoda vasica leaf juice by quantification of total alkaloids and vasicine". Indian Journal of Pharmaceutical Sciences 70 (1): 36–42. doi:10.4103/0250-474X.40329. ISSN 0250-474X. PMID 20390078.
 |  |
