Medicine:Salpingo-oophorectomy
A salpingo-oophorectomy is the removal of an ovary and its fallopian tube.[1][2] As a risk-reducing surgery, this procedure is the most effective form of prevention in women carrying gene mutations which put them at higher risk of developing ovarian cancer, such as a BRCA mutation.[3] It is particularly important in mutations of the normally tumor suppressing BRCA1 gene, or, with a statistically lower negative impact, in those of the tumour suppressing BRCA2 gene, which can increase the risk of developing ovarian cancer to as high as 65% and 25%, respectively.[4]
In a bilateral salpingo-oophorectomy (BSO) both ovaries are removed, leading to a surgical menopause, as the body is deprived of estrogen, a hormone normally produced in the ovaries. Hormone replacement therapy is generally recommended after BSO, unless there is a history of triple-negative breast cancer.[5]
See also
References
- ↑ "Salpingo-Oophorectomy: Overview, Periprocedural Care, Technique". 7 February 2018. https://emedicine.medscape.com/article/1894587-overview. Retrieved 2 December 2018.
- ↑ "bilateral salpingo-oophorectomy". https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bilateral-salpingo-oophorectomy. Retrieved 23 March 2022.
- ↑ Caruso, Giuseppe; Weroha, S. John; Cliby, William (2025-10-14). "Ovarian Cancer: A Review" (in en). JAMA 334 (14): 1278. doi:10.1001/jama.2025.9495. ISSN 0098-7484. https://jamanetwork.com/journals/jama/fullarticle/2836686.
- ↑ "Laparoscopic Salpingo-Oophorectomy". https://med.emory.edu/departments/gynecology-obstetrics/patient-care/patient-education/salpingo-oophorectomy/index.html#:~:text=A%20salpingo%2Doophorectomy%20is%20the,incisions%20on%20your%20lower%20abdomen.. Retrieved 23 March 2022.
- ↑ Jörg, Inna; Chronas, Dimitrios (2026-03-07). "Hormonal management after risk-reducing surgery in BRCA-mutated triple-negative breast cancer survivors". Journal of Cancer Research and Clinical Oncology 152 (3): 60. doi:10.1007/s00432-026-06425-9. ISSN 1432-1335. PMID 41793502. PMC 12967752. https://pubmed.ncbi.nlm.nih.gov/41793502.
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