Medicine:Oophorectomy

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Short description: Surgical removal of the ovary or ovaries
Oophorectomy
ICD-10-PCS0UB00ZX - 0UB28ZZ
ICD-9-CM65.3-65.6
MeSHD010052

Oophorectomy (/ˌoʊ.əfəˈrɛktəmi/; from Greek ᾠοφόρος, ōophóros, 'egg-bearing' and ἐκτομή, ektomḗ, 'a cutting out of'), historically also called ovariotomy, is the surgical removal of an ovary or ovaries.[1] The surgery is also called ovariectomy, but this term is mostly used in reference to non-human animals, e.g. the surgical removal of ovaries from laboratory animals. Removal of the ovaries of females is the biological equivalent of castration of males; the term castration is only occasionally used in the medical literature to refer to oophorectomy of women. In veterinary medicine, the removal of ovaries and uterus is called ovariohysterectomy (spaying) and is a form of sterilization.

The first reported successful human oophorectomy was carried out by (Sir) Sydney Jones at Sydney Infirmary, Australia, in 1870.[2]

Partial oophorectomy or ovariotomy is a term sometimes used to describe a variety of surgeries such as ovarian cyst removal, or resection of parts of the ovaries.[3] This kind of surgery is fertility-preserving, although ovarian failure may be relatively frequent. Most of the long-term risks and consequences of oophorectomy are not or only partially present with partial oophorectomy.

In humans, oophorectomy is most often performed because of diseases such as ovarian cysts or cancer; as prophylaxis to reduce the chances of developing ovarian cancer or breast cancer; or in conjunction with hysterectomy (removal of the uterus). In the 1890s people believed oophorectomies could cure menstrual cramps, back pain, headaches, and chronic coughing, although no evidence existed that the procedure impacted any of these ailments.[4]

The removal of an ovary together with the fallopian tube is called salpingo-oophorectomy or unilateral salpingo-oophorectomy (USO). When both ovaries and both fallopian tubes are removed, the term bilateral salpingo-oophorectomy (BSO) is used. Oophorectomy and salpingo-oophorectomy are not common forms of birth control in humans; more usual is tubal ligation, in which the fallopian tubes are blocked but the ovaries remain intact. In many cases, surgical removal of the ovaries is performed concurrently with a hysterectomy. The formal medical name for removal of a woman's entire reproductive system (ovaries, fallopian tubes, uterus) is "total abdominal hysterectomy with bilateral salpingo-oophorectomy" (TAH-BSO); the more casual term for such a surgery is "ovariohysterectomy". "Hysterectomy" is removal of the uterus (from the Greek ὑστέρα hystera "womb" and εκτομία ektomia "a cutting out of") without removal of the ovaries or fallopian tubes.

Technique

Oophorectomy for benign causes is most often performed by abdominal laparoscopy. Abdominal laparotomy or robotic surgery is used in complicated cases or when a malignancy is suspected.[citation needed]

Statistics

According to the Centers for Disease Control, 454,000 women in the United States underwent oophorectomy in 2004. The first successful operation of this type, account of which was published in the Eclectic Repertory and Analytic Review (Philadelphia) in 1817, was performed by Ephraim McDowell (1771-1830), a surgeon from Danville, Kentucky.[5] McDowell was dubbed as the "father of ovariotomy".[6][7] It later became known as Battey's Operation, after Robert Battey, a surgeon from Augusta, Georgia, who championed the procedure for a variety of conditions, most successfully for ovarian epilepsy.[8]

Indication

Most bilateral oophorectomies (63%) are performed without any medical indication, and most (87%) are performed together with a hysterectomy.[9] Conversely, unilateral oophorectomy is commonly performed for a medical indication (73%; cyst, endometriosis, benign tumor, inflammation, etc.) and less commonly in conjunction with hysterectomy (61%).[9]

Special indications include several groups of women with substantially increased risk of ovarian cancer, such as high-risk BRCA mutation carriers and women with endometriosis who also have frequent ovarian cysts.[citation needed]

Bilateral oophorectomy has been traditionally done in the belief that the benefit of preventing ovarian cancer would outweigh the risks associated with removal of ovaries. However, it is now clear that prophylactic oophorectomy without a reasonable medical indication decreases long-term survival rates substantially[10] and has deleterious long-term effects on health and well-being even in post-menopausal women.[11] The procedure has been postulated as a possible treatment method for female sex offenders.[12]

The procedure is sometimes performed at the same time as hysterectomy in transgender men and non-binary people. The long term effects of oophorectomy in this population are not well studied.[13]

Cancer prevention

Oophorectomy can significantly improve survival for women with high-risk BRCA mutations, for whom prophylactic oophorectomy around age 40 reduces the risk of ovarian and breast cancer and provides significant and substantial long-term survival advantage.[14] On average, earlier intervention does not provide any additional benefit but increases risks and adverse effects.

For women with high-risk BRCA2 mutations, oophorectomy around age 40 has a relatively modest benefit for survival; the positive effect of reduced breast and ovarian cancer risk is nearly balanced by adverse effects. The survival advantage is more substantial when oophorectomy is performed together with prophylactic mastectomy.[15][16]

The risks and benefits associated with oophorectomy in the BRCA1/2 mutation carrier population are different than those for the general population. Prophylactic risk-reducing salpingo-oophorectomy (RRSO) is an important option for the high-risk population to consider. Women with BRCA1/2 mutations who undergo salpingo-oophorectomy have lower all-cause mortality rates than women in the same population who do not undergo this procedure. In addition, RRSO has been shown to decrease mortality specific to breast cancer and ovarian cancer. Women who undergo RRSO are also at a lower risk for developing ovarian cancer and first occurrence breast cancer. Specifically, RRSO provides BRCA1 mutation carriers with no prior breast cancer a 70% reduction of ovarian cancer risk. BRCA1 mutation carriers with prior breast cancer can benefit from an 85% reduction. High-risk women who have not had prior breast cancer can benefit from a 37% (BRCA1 mutation) and 64% (BRCA2 mutation) reduction of breast cancer risk. These benefits are important to highlight, as they are unique to this BRCA1/2 mutation carrier population.[17]

Endometriosis

In rare cases, oophorectomy can be used to treat endometriosis by eliminating the menstrual cycle, which will reduce or eliminate the spread of existing endometriosis as well as reducing pain. Since endometriosis results from an overgrowth of the uterine lining, removal of the ovaries as a treatment for endometriosis is often done in conjunction with a hysterectomy to further reduce or eliminate recurrence.[citation needed]

Oophorectomy for endometriosis is used only as last resort, often in conjunction with a hysterectomy, as it has severe side effects for women of reproductive age. However, it has a higher success rate than retaining the ovaries.[18]

Partial oophorectomy (i.e., ovarian cyst removal not involving total oophorectomy) is often used to treat milder cases of endometriosis when non-surgical hormonal treatments fail to stop cyst formation. Removal of ovarian cysts through partial oophorectomy is also used to treat extreme pelvic pain from chronic hormonal-related pelvic problems.

Risks and adverse effects

Surgical risks

Oophorectomy is an intra-abdominal surgery and serious complications stemming directly from the surgery are rare. When performed together with hysterectomy, it has influence on choice of surgical technique as the combined surgery is much less likely to be performed by vaginal hysterectomy.[citation needed]

Laparotomic adnexal surgeries are associated with a high rate of adhesive small bowel obstructions (24%).[19]

An infrequent complication is injuring of the ureter at the level of the suspensory ligament of the ovary.[20]

Long-term effects

Oophorectomy has serious long-term consequences stemming mostly from the hormonal effects of the surgery and extending well beyond menopause. The reported risks and adverse effects include premature death,[21][22] cardiovascular disease, cognitive impairment or dementia,[23] parkinsonism,[24] osteoporosis and bone fractures, decline in psychological well-being,[25] and decline in sexual function. Hormone replacement therapy does not always reduce the adverse effects.[10]

Mortality

Oophorectomy is associated with significantly increased all-cause long-term mortality except when performed for cancer prevention in carriers of high-risk BRCA mutations. This effect is particularly pronounced for women who undergo oophorectomy before age 45.[22]

The effect is not limited to women who have oophorectomy performed before menopause; an impact on survival is expected even for surgeries performed up to the age of 65.[26] Surgery at age 50-54 reduces the probability of survival until age 80 by 8% (from 62% to 54% survival), surgery at age 55-59 by 4%. Most of this effect is due to excess cardiovascular risk and hip fractures.[26]

Removal of ovaries causes hormonal changes and symptoms similar to, but generally more severe than, menopause. Women who have had an oophorectomy are usually encouraged to take hormone replacement drugs to prevent other conditions often associated with menopause. Women younger than 45 who have had their ovaries removed face a mortality risk 170% higher than women who have retained their ovaries.[22] Retaining the ovaries when a hysterectomy is performed is associated with better long-term survival.[21] Hormone therapy for women with oophorectomies performed before age 45 improves the long-term outcome and all-cause mortality rates.[22][27]

Menopausal effects

Women who have had bilateral oophorectomy surgeries lose most of their ability to produce the hormones estrogen and progesterone, and lose about half of their ability to produce testosterone, and subsequently enter what is known as "surgical menopause" (as opposed to normal menopause, which occurs naturally in women as part of the aging process). In natural menopause the ovaries generally continue to produce low levels of hormones, especially androgens, long after menopause, which may explain why surgical menopause is generally accompanied by a more sudden and severe onset of symptoms than natural menopause, symptoms that may continue until the natural age of menopause.[28] These symptoms are commonly addressed through hormone therapy, utilizing various forms of estrogen, testosterone, progesterone, or a combination.[citation needed]

Cardiovascular risk

When the ovaries are removed, a woman is at a seven times greater risk of cardiovascular disease,[29][30][31] but the mechanisms are not precisely known. The hormone production of the ovaries currently cannot be sufficiently mimicked by drug therapy. The ovaries produce hormones a woman needs throughout her entire life, in the quantity they are needed, at the time they are needed, in response to and as part of the complex endocrine system.

Osteoporosis

Oophorectomy is associated with an increased risk of osteoporosis and bone fractures.[32][33][34][35][36] A potential risk for oophorectomy performed after menopause is not fully elucidated.[37][38] Reduced levels of testosterone in women is predictive of height loss, which may occur as a result of reduced bone density.[39] In women under the age of 50 who have undergone oophorectomy, hormone replacement therapy (HRT) is often used to offset the negative effects of sudden hormonal loss such as early-onset osteoporosis as well as menopausal problems like hot flashes that are usually more severe than those experienced by women undergoing natural menopause.

Adverse effect on sexuality

Oophorectomy substantially impairs sexuality.[40] Substantially more women who had both an oophorectomy and a hysterectomy reported libido loss, difficulty with sexual arousal, and vaginal dryness than those who had a less invasive procedure (either hysterectomy alone or an alternative procedure), and hormone replacement therapy was not found to improve these symptoms.[41] In addition, oophorectomy greatly reduces testosterone levels, which are associated with a greater sense of sexual desire in women.[42] However, at least one study has shown that psychological factors, such as relationship satisfaction, are still the best predictor of sexual activity following oophorectomy.[43] Sexual intercourse remains possible after oophorectomy and coitus can continue. Reconstructive surgery remains an option for women who have experienced benign and malignant conditions.[44] :1020–1348

Managing side effects of prophylactic oophorectomy

Non-hormonal treatments

The side effects of oophorectomy may be alleviated by medicines other than hormonal replacement. Non-hormonal biphosphonates (such as Fosamax and Actonel) increase bone strength and are available as once-a-week pills. Low-dose selective serotonin reuptake inhibitors such as Paxil and Prozac alleviate vasomotor menopausal symptoms, i.e., "hot flashes".[45]

Hormonal treatments

In general, hormone replacement therapy is somewhat controversial due to the known carcinogenic and thrombogenic properties of estrogen; however, many physicians and patients feel the benefits outweigh the risks in women who may face serious health and quality-of-life issues as a consequence of early surgical menopause. The ovarian hormones estrogen, progesterone, and testosterone are involved in the regulation of hundreds of bodily functions; it is believed by some doctors that hormone therapy programs mitigate surgical menopause side effects such as increased risk of cardiovascular disease,[46] and female sexual dysfunction.[47]

Short-term hormone replacement with estrogen has negligible effect on overall mortality for high-risk BRCA mutation carriers. Based on computer simulations, overall mortality appears to be marginally higher for short-term HRT after oophorectomy or marginally lower for short-term HRT after oophorectomy in combination with mastectomy.[48] This result can probably be generalized to other women at high risk in whom short-term (i.e., one- or two-year) treatment with estrogen for hot flashes may be acceptable.

See also

References

  1. ↑ "About - Mayo Clinic" (in en). https://www.mayoclinic.org/tests-procedures/oophorectomy/about/pac-20385030?p=1. 
  2. ↑ John Garrett: "Jones, Sir Philip Sydney (1836–1918)", Australian Dictionary of Biography, 1972
  3. ↑ "Definition of "ovariotomy" at Collins Dictionary". http://www.collinsdictionary.com/dictionary/english/ovariotomy. 
  4. ↑ Bryson, Bill (2019). "In the Beginning: Conception and Birth". The Body (1st ed.). New York: Penguin Random House. p. 295. ISBN 9780385539302. 
  5. ↑ McDowell, Ephraim (1817). "Three cases of extirpation of diseased ovaries". Eclectic Repertory & Analytic Review 7: 242–244. 
  6. ↑ Lewis S. Pilcher. Ephraim McDowell, Father of Ovariotomy and Founder of Abdominal Surgery, Annals of Surgery, 1922 (January), Volume 75 (1), p. 125–126.
  7. ↑ The Biographical Dictionary of America, vol. 7, p. 147.
  8. ↑ Thiery, Michel (1998). "Battey's operation: an exercise in surgical frustration". European Journal of Obstetrics & Gynecology and Reproductive Biology 81 (2): 243–246. doi:10.1016/s0301-2115(98)00197-3. PMID 9989872. 
  9. ↑ 9.0 9.1 "Bilateral oophorectomy trends in Olmsted County, Minnesota, 1950-1987". Epidemiology 2 (2): 149–52. Mar 1991. doi:10.1097/00001648-199103000-00011. PMID 1932314. 
  10. ↑ 10.0 10.1 "Prophylactic oophorectomy in premenopausal women and long-term health". Menopause Int. 14 (3): 111–6. Sep 2008. doi:10.1258/mi.2008.008016. PMID 18714076. 
  11. ↑ Bhattacharya, S. M.; Jha, A. (2010). "A comparison of health-related quality of life (HRQOL) after natural and surgical menopause". Maturitas 66 (4): 431–434. doi:10.1016/j.maturitas.2010.03.030. PMID 20434859. 
  12. ↑ "Alabama lawmaker proposes castration bill for sex offenders". 7 March 2016. http://www.salon.com/2016/03/07/alabama_lawmaker_proposes_castration_bill_for_sex_offenders/. 
  13. ↑ Kumar, Sahil; Mukherjee, Smita; O'Dwyer, Cormac; Wassersug, Richard; Bertin, Elise; Mehra, Neeraj; Dahl, Marshall; Genoway, Krista et al. (2022). "Health Outcomes Associated With Having an Oophorectomy Versus Retaining One's Ovaries for Transmasculine and Gender Diverse Individuals Treated With Testosterone Therapy: A Systematic Review". Sexual Medicine Reviews 10 (4): 636–647. doi:10.1016/j.sxmr.2022.03.003. https://academic.oup.com/smr/article-abstract/10/4/636/7016893. 
  14. ↑ "Challenging and Complex Decisions in the Management of the BRCA Mutation Carrier". Journal of Women's Health 22 (10): 825–834. October 2013. doi:10.1089/jwh.2013.4407. PMID 23987739. 
  15. ↑ Kurian, A.; Sigal, B.; Plevritis, S. (2010). "Survival analysis of cancer risk reduction strategies for BRCA1/2 mutation carriers.". Journal of Clinical Oncology 28 (2): 222–231. doi:10.1200/JCO.2009.22.7991. PMID 19996031. 
  16. ↑ Stadler, Z. K.; Kauff, N. D. (2009). "Weighing Options for Cancer Risk Reduction in Carriers of BRCA1 and BRCA2 Mutations". Journal of Clinical Oncology 28 (2): 189–91. doi:10.1200/JCO.2009.25.6875. PMID 19996025. 
  17. ↑ "Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality". JAMA 304 (9): 967–75. September 2010. doi:10.1001/jama.2010.1237. PMID 20810374. 
  18. ↑ "Recurrence of endometriosis after hysterectomy". Facts Views Vis Obgyn 6 (4): 219–27. 2014. PMID 25593697. 
  19. ↑ Barmparas, G.; Branco, B. C.; Schnüriger, B.; Lam, L.; Inaba, K.; Demetriades, D. (2010). "The Incidence and Risk Factors of Post-Laparotomy Adhesive Small Bowel Obstruction". Journal of Gastrointestinal Surgery 14 (10): 1619–1628. doi:10.1007/s11605-010-1189-8. PMID 20352368. 
  20. ↑ "Oophorectomy with Transection of Ureter - Medical Illustration, Human Anatomy Drawing, Anatomy Illustration". https://graphicwitness.medicalillustration.com/generateexhibit.php?ID=10847&TC=&A=58650. 
  21. ↑ 21.0 21.1 "Ovarian conservation at the time of hysterectomy for benign disease". Obstet Gynecol 106 (2): 219–26. August 2005. doi:10.1097/01.AOG.0000167394.38215.56. PMID 16055568. 
  22. ↑ 22.0 22.1 22.2 22.3 "Survival patterns after oophorectomy in premenopausal women: a population-based cohort study". Lancet Oncol. 7 (10): 821–8. Oct 2006. doi:10.1016/S1470-2045(06)70869-5. PMID 17012044. 
  23. ↑ "Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause". Neurology 69 (11): 1074–83. Sep 2007. doi:10.1212/01.wnl.0000276984.19542.e6. PMID 17761551. 
  24. ↑ "Increased risk of parkinsonism in women who underwent oophorectomy before menopause". Neurology 70 (3): 200–9. Jan 2008. doi:10.1212/01.wnl.0000280573.30975.6a. PMID 17761549. 
  25. ↑ "Long-term risk of depressive and anxiety symptoms after early bilateral oophorectomy". Menopause 15 (6): 1050–9. Nov–Dec 2008. doi:10.1097/gme.0b013e318174f155. PMID 18724263. 
  26. ↑ 26.0 26.1 Shoupe, D.; Parker, W. H.; Broder, M. S.; Liu, Z.; Farquhar, C.; Berek, J. S. (2007). "Elective oophorectomy for benign gynecological disorders". Menopause 14 (Suppl. 1): 580–585. doi:10.1097/gme.0b013e31803c56a4. PMID 17476148. 
  27. ↑ "News and views". Menopause Int 12 (4): 133–7. December 2006. doi:10.1258/136218006779160472. http://mi.rsmjournals.com/cgi/reprint/12/4/133?hits=10&FIRSTINDEX=0&SEARCHID=1&gca=rsmmi%3B12%2F4%2F133&. Retrieved 2009-07-03. "Further evidence in favour of HRT in early menopause". 
  28. ↑ "Medical Definition of Surgical menopause". http://www.medterms.com/script/main/art.asp?articlekey=8952. 
  29. ↑ "Time interval from castration in premenopausal women to development of excessive coronary atherosclerosis". Am. J. Obstet. Gynecol. 99 (2): 155–62. 1967. doi:10.1016/0002-9378(67)90314-6. PMID 6039061. 
  30. ↑ "Menopause and the risk of coronary heart disease in women". N. Engl. J. Med. 316 (18): 1105–10. April 1987. doi:10.1056/NEJM198704303161801. PMID 3574358. 
  31. ↑ "Increased cardiovascular mortality after early bilateral oophorectomy". Menopause 16 (1): 15–23. Jan–Feb 2009. doi:10.1097/gme.0b013e31818888f7. PMID 19034050. 
  32. ↑ "Risk factors for pelvis fracture in older persons". Am. J. Epidemiol. 162 (9): 879–86. November 2005. doi:10.1093/aje/kwi295. PMID 16221810. 
  33. ↑ "Risk factors for osteoporosis related to their outcome: fractures". Osteoporos Int 12 (8): 630–8. 2001. doi:10.1007/s001980170062. PMID 11580076. http://link.springer.de/link/service/journals/00198/bibs/1012008/10120630.htm. Retrieved 2009-07-03. 
  34. ↑ "Effects of natural menopause, hysterectomy, and oophorectomy on lumbar spine and femoral neck bone densities". Obstet Gynecol 72 (4): 631–8. October 1988. PMID 3419740. 
  35. ↑ Levin RJ (October 2002). "The physiology of sexual arousal in the human female: a recreational and procreational synthesis". Arch Sex Behav 31 (5): 405–11. doi:10.1023/A:1019836007416. PMID 12238607. http://www.kluweronline.com/art.pdf?issn=0004-0002&volume=31&page=405. 
  36. ↑ Masters, W.H., et al. The Uterus, Physiological and Clinical Considerations Human Sexual Response 1966 p.111-140
  37. ↑ Melton, L. J.; Khosla, S.; Malkasian, G. D.; Achenbach, S. J.; Oberg, A. L.; Riggs, B. L. (2003). "Fracture Risk After Bilateral Oophorectomy in Elderly Women". Journal of Bone and Mineral Research 18 (5): 900–905. doi:10.1359/jbmr.2003.18.5.900. PMID 12733730. 
  38. ↑ "Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older women". J Bone Miner Res 20 (5): 741–7. May 2005. doi:10.1359/JBMR.041220. PMID 15824846. 
  39. ↑ "Low bioavailable testosterone levels predict future height loss in postmenopausal women". J. Bone Miner. Res. 10 (4): 650–4. April 1995. doi:10.1002/jbmr.5650100419. PMID 7610937. 
  40. ↑ Castelo-Branco, C.; Palacios, S.; Combalia, J.; Ferrer, M.; Traveria, G. (2009). "Risk of hypoactive sexual desire disorder and associated factors in a cohort of oophorectomized women". Climacteric 12 (6): 525–532. doi:10.3109/13697130903075345. PMID 19905904. 
  41. ↑ "Psychosexual health 5 years after hysterectomy: population-based comparison with endometrial ablation for dysfunctional uterine bleeding". Health Expectations 8 (3): 234–43. September 2005. doi:10.1111/j.1369-7625.2005.00338.x. PMID 16098153. 
  42. ↑ Shifren, JL (2002). "Androgen deficiency in the oophorectomized woman". Fertility and Sterility 77 (Suppl 4): S60–2. doi:10.1016/s0015-0282(02)02970-9. PMID 12007904. .
  43. ↑ Lorenz, T.; McGregor, B.; Swisher, E. (2014). "Relationship satisfaction predicts sexual activity following risk-reducing salpingo-oophorectomy". Journal of Psychosomatic Obstetrics & Gynecology 35 (2): 62–8. doi:10.3109/0167482X.2014.899577. PMID 24693956. 
  44. ↑ Hoffman, Barbara (2012). Williams gynecology (2nd ed.). New York: McGraw-Hill Medical. p. 65. ISBN 978-0071716727. 
  45. ↑ "Menopause Symptoms, Treatments and Stages of Menopause". Brigham and Women's Hospital, Boston, Massachusetts. 2007-04-26. http://www.brighamandwomens.org/patient/menopauseqanda.asp. 
  46. ↑ Ben Hirschler, "Expert believes early HRT can have heart benefits" 21 December 2006; Reuters Health
  47. ↑ "Female hypoactive sexual disorder: case studies of physiologic androgen replacement". J Sex Marital Ther 25 (3): 175–82. 1999. doi:10.1080/00926239908403992. PMID 10407790. http://taylorandfrancis.metapress.com/(td4exhbuyrorb455ocw2krve)/app/home/contribution.asp?referrer=parent&backto=issue,1,8;journal,39,40;linkingpublicationresults,1:102471,1. 
  48. ↑ "Hormone replacement therapy and life expectancy after prophylactic oophorectomy in women with BRCA1/2 mutations: a decision analysis". J. Clin. Oncol. 22 (6): 1045–54. 2004. doi:10.1200/JCO.2004.06.090. PMID 14981106. 

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