Medicine:XY gonadal dysgenesis

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"Swyer syndrome" redirects here. For the lung condition, see Swyer–James syndrome.
XY gonadal dysgenesis
Other namesSwyer syndrome
Protein SRY
SpecialtyMedical genetics

XY complete gonadal dysgenesis, also known as Swyer syndrome, is a condition resulting in a female phenotype in an individual with a 46,XY karyotype. Though they typically have normal vulvas,[1] those affected typically have underdeveloped gonads, fibrous tissue termed "streak gonads", and without hormone replacement therapy, typically will not experience puberty. The cause is often, but not always, inactivation of the SRY gene, which is responsible for sexual differentiation. Pregnancy is sometimes possible in Swyer syndrome with assisted reproductive technology,[2][3][4][5] and, in at least one case, without it.[6]

The syndrome was named after Gerald Swyer, an endocrinologist based at London's University College Hospital, who first reported two cases in 1955.[7]

Signs and symptoms

Those with Swyer syndrome develop phenotypes typical of females and nonfunctional gonads. Individuals are most commonly diagnosed during adolescence after puberty fails to occur.[8]

The consequences of Swyer syndrome without treatment:

  • The individual's gonads do not have two X chromosomes, so the breasts will not develop and the uterus will not grow and menstruate until estrogen is administered. This is often given transdermally.
  • Their gonads cannot make progesterone, so menstrual periods will not be predictable until progestin is administered, usually as a pill.
  • Their gonads cannot produce eggs, so conceiving children is not possible.
  • Streak gonads with Y chromosome-containing cells have a high likelihood of developing cancer, especially gonadoblastoma.[9] Streak gonads are usually removed within a year or so of diagnosis, since the cancer can begin during infancy.[10]
  • Osteopenia is often present.[11]

Genetics

Genetic associations of Swyer syndrome include:

Type OMIM Gene Locus
46,XY gonadal dysgenesis, complete, SRY-related Online Mendelian Inheritance in Man (OMIM) 400044 SRY Yp11.3
46,XY gonadal dysgenesis, complete or partial, DHH-related Online Mendelian Inheritance in Man (OMIM) 233420 DHH 12q13.1
46,XY gonadal dysgenesis, complete or partial, with or without adrenal failure Online Mendelian Inheritance in Man (OMIM) 612965 NR5A1 9q33
46,XY gonadal dysgenesis, complete, CBX2-related Online Mendelian Inheritance in Man (OMIM) 613080 CBX2 17q25
46,XY gonadal dysgenesis, complete or partial, with 9p24.3 deletion Online Mendelian Inheritance in Man (OMIM) 154230 DMRT1/2 9p24.3

Seven other genes have been identified with probable associations that are as yet less clearly understood.[12]

Pure gonadal dysgenesis

There are several forms of gonadal dysgenesis. The term "pure gonadal dysgenesis" (PGD) has been used to describe conditions with normal sets of sex chromosomes (e.g., 46,XX or 46,XY), as opposed to those whose gonadal dysgenesis results from missing all or part of the second sex chromosome.[13] The latter group includes those with Turner syndrome (i.e., 45,X) and its variants, as well as those with mixed gonadal dysgenesis and a mixture of cell lines, some containing a Y chromosome (e.g., 46,XY/45,X).[14]

Thus Swyer syndrome is referred to as PGD, 46,XY, and XX gonadal dysgenesis as PGD, 46,XX.[15] People with PGD have a normal karyotype but may have defects of a specific gene on a chromosome.

In 2007, a case was reported of a woman with 46,XY complete gonadal dysgenesis whose mother had Turners Syndrome mosaicism with a 46,XY karyotype in peripheral lymphocytes, 80% 46,XY and 20% 45,X in cultured skin fibroblasts, and 93% 46,XY, 6% 45,X, and <1% 46,XX in the ovary.[16]

Pathogenesis

The first known step of sexual differentiation of a male fetus is the development of testes. The early stages of testicular formation in the second month of gestation require the action of several genes, one of the earliest and most important of which is SRY: the sex-determining region of the Y chromosome.[17][18]

When such a gene is defective, the indifferent gonads fail to differentiate into testes in an XY fetus. Without testes, no testosterone or anti-Müllerian hormone (AMH) is produced. Without testosterone, the Wolffian ducts fail to develop, so no internal male organs are formed. Also, the lack of testosterone means that no dihydrotestosterone is formed and consequently the external genitalia fail to virilize, resulting in a normal vulva.[19] Without AMH, the Müllerian ducts develop into normal internal female organs (uterus, fallopian tubes, cervix, vagina).[20]

Diagnosis

Due to the inability of the streak gonads to produce sex hormones (both estrogens and androgens), most of the secondary sex characteristics do not develop. This is especially true of estrogenic changes such as breast development, widening of the pelvis and hips, and menstrual periods.[21] As the adrenal glands can make limited amounts of androgens and are not affected by this syndrome, most of these persons will develop pubic hair, though it often remains sparse.[22]

Evaluation of delayed puberty usually reveals elevation of gonadotropins, indicating that the pituitary is providing the signal for puberty but the gonads are failing to respond. The next steps of the evaluation usually include checking a karyotype and imaging of the pelvis.[23] The karyotype reveals XY chromosomes and the imaging demonstrates the presence of a uterus but no ovaries (the streak gonads are not usually seen by most imaging). Although an XY karyotype can also indicate a person with complete androgen insensitivity syndrome, the absence of breasts, and the presence of a uterus and pubic hair exclude the possibility. At this point it is usually possible for a physician to make a diagnosis of Swyer syndrome.[24]

Swyer syndrome represents one phenotypic result of a failure of the gonads to develop properly, and hence is part of a class of conditions termed gonadal dysgenesis. There are many forms of gonadal dysgenesis.[25]

Swyer syndrome is an example of a condition in which an externally unambiguous female body carries dysgenetic, atypical, or abnormal gonads.[26] Other examples include complete androgen insensitivity syndrome, partial X chromosome deletions, lipoid congenital adrenal hyperplasia, and Turner syndrome.[27]

Treatment

Upon diagnosis, estrogen and progestogen therapy is typically commenced, promoting the development of female characteristics.

Hormone replacement therapy can also reduce the likelihood of osteoporosis.[1]

Epidemiology

A 2017 study estimated that the incidence of Swyer syndrome is approximately 1 in 100,000 females.[28] Fewer than 100 cases have been reported as of 2018. There are extremely rare instances of familial Swyer syndrome.[29] [30]

People with XY gonadal dysgenesis

  • Arisleyda Dilone, American director and actress[31]
  • Sara Forsberg, Finnish singer, songwriter, and television presenter[32]

See also

References

  1. ↑ 1.0 1.1 "Swyer Syndrome". https://medlineplus.gov/genetics/condition/swyer-syndrome/. 
  2. ↑ Taneja, Jyoti; Ogutu, David; Ah-Moye, Michael (18 October 2016). "Rare successful pregnancy in a patient with Swyer Syndrome". Case Reports in Women's Health 12: 1–2. doi:10.1016/j.crwh.2016.10.001. ISSN 2214-9112. PMID 29629300. 
  3. ↑ Urban, Aleksandra; Knap-Wielgus, Weronika; Grymowicz, Monika; Smolarczyk, Roman (September 2021). "Two successful pregnancies after in vitro fertilisation with oocyte donation in a patient with Swyer syndrome – a case report". Przegla̜d Menopauzalny = Menopause Review 20 (3): 158–161. doi:10.5114/pm.2021.109361. ISSN 1643-8876. PMID 34703418. 
  4. ↑ Gupta, Anupam; Bajaj, Ritika; Jindal, Umesh N. (2019). "A Rare Case of Swyer Syndrome in Two Sisters with Successful Pregnancy Outcome in Both". Journal of Human Reproductive Sciences 12 (3): 267–269. doi:10.4103/jhrs.JHRS_14_19. ISSN 0974-1208. PMID 31576088. 
  5. ↑ "Review and management of 46,XY disorders of sex development.". J Pediatr Urol 9 (3): 368–379. 29 December 2012. doi:10.1016/j.jpurol.2012.12.002. PMID 23276787. 
  6. ↑ Dumic, Miroslav; Lin-Su, Karen; Leibel, Natasha I.; Ciglar, Srecko; Vinci, Giovanna; Lasan, Ruzica; Nimkarn, Saroj; Wilson, Jean D. et al. (January 2008). "Report of fertility in a woman with a predominantly 46,XY karyotype in a family with multiple disorders of sexual development". The Journal of Clinical Endocrinology and Metabolism 93 (1): 182–189. doi:10.1210/jc.2007-2155. ISSN 0021-972X. PMID 18000096. 
  7. ↑ Swyer GIM (17 September 1955). "Male Pseudohermaphroditism: A Hitherto Undescribed Form". Br. Med. J. 2 (4941): 709–712. doi:10.1136/bmj.2.4941.709. PMID 13250193. 
  8. ↑ "Swyer syndrome". https://rarediseases.org/rare-diseases/swyer-syndrome/. 
  9. ↑ Eh, Zheng; Liu, Weili (June 1994). "A familial 46 XY gonadal dysgenesis and high incidence of embryonic gonadal tumors". Chinese Journal of Cancer Research 6 (2): 144–148. doi:10.1007/BF02997250.  Originally published in Chinese as E, Z; Xu, XL; Li, C; Gao, FZ (May 1981). "家族性XY型性腺发育不全和高发胚胎性肿瘤研究：II．XY型性腺发育不全姐妹中第4人继发无性细胞瘤报告和细胞遗传学检查" (in zh). Zhonghua Zhong Liu Za Zhi 3 (2): 89–90. PMID 7307902. http://rs.yiigle.com/CN112152198102/979134.htm. 
  10. ↑ Piazza, Mauri José; Urbanetz, Almir Antonio (2019). "Germ Cell Tumors in Dysgenetic Gonads". Clinics 74: e408. doi:10.6061/clinics/2019/e408. ISSN 1980-5322. PMID 31721911. PMC 6827326. https://pmc.ncbi.nlm.nih.gov/articles/PMC6827326/. 
  11. ↑ Michala, L.; Goswami, D.; Creighton, SM; Conway, GS (2008). "Swyer syndrome: Presentation and outcomes". BJOG: An International Journal of Obstetrics and Gynaecology 115 (6): 737–741. doi:10.1111/j.1471-0528.2008.01703.x. PMID 18410658. https://obgyn.onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-0528.2008.01703.x. Retrieved 11 January 2021. 
  12. ↑ "Recent findings on the genetics of disorders of sex development". Curr Opin Urol 27 (1): 1–6. January 2017. doi:10.1097/MOU.0000000000000353. PMID 27798415. 
  13. ↑ Rebar, Robert W.; Erickson, Gregory F. (2012-01-01), "244 - Reproductive Endocrinology and Infertility", in Goldman, Lee; Schafer, Andrew I., Goldman's Cecil Medicine (Twenty Fourth Edition), Philadelphia: W.B. Saunders, pp. 1534–1546, doi:10.1016/B978-1-4377-1604-7.00244-X, ISBN 978-1-4377-1604-7, https://www.sciencedirect.com/science/article/pii/B978143771604700244X, retrieved 2026-07-17 
  14. ↑ Breehl, Logen; Caban, Omar (2026), "Genetics, Gonadal Dysgenesis", StatPearls (Treasure Island (FL): StatPearls Publishing), PMID 30969708, http://www.ncbi.nlm.nih.gov/books/NBK539886/, retrieved 2026-07-17 
  15. ↑ Bomalaski, M. David (February 2005). "A practical approach to intersex". Urologic Nursing 25 (1): 11–8, 23; quiz 24. PMID 15779688. https://www.medscape.com/viewarticle/499501_5. 
  16. ↑ Dumic, Miroslav; Lin-Su, Karen; Leibel, Natasha I.; Ciglar, Srecko; Vinci, Giovanna; Lasan, Ruzica; Nimkarn, Saroj; Wilson, Jean D. et al. (2008-01-01). "Report of Fertility in a Woman with a Predominantly 46,XY Karyotype in a Family with Multiple Disorders of Sexual Development" (in en). The Journal of Clinical Endocrinology & Metabolism 93 (1): 182–189. doi:10.1210/jc.2007-2155. ISSN 0021-972X. PMID 18000096. PMC 2190741. https://academic.oup.com/jcem/article/93/1/182/2598461. 
  17. ↑ "SRY gene: MedlinePlus Genetics" (in en). https://medlineplus.gov/genetics/gene/sry/. 
  18. ↑ "SRY sex determining region Y [Homo sapiens (human) - Gene - NCBI"]. https://www.ncbi.nlm.nih.gov/gene/6736. 
  19. ↑ Silverman, Ann-Judith. "Gonadal Development". Department of Anatomy & Cell Biology 14 (1). http://www.columbia.edu/itc/hs/medical/humandev/2004/Chpt14-GonadalDev.pdf. 
  20. ↑ Wilson, Danielle; Bordoni, Bruno (2022), "Embryology, Mullerian Ducts (Paramesonephric Ducts)", StatPearls (Treasure Island, Florida: StatPearls Publishing), PMID 32491659, https://www.ncbi.nlm.nih.gov/books/NBK557727/, retrieved 2023-01-20 
  21. ↑ "Gonadal and Placental Hormones" (in en). The Endocrine System 1 (1). 2013-03-06. https://pressbooks-dev.oer.hawaii.edu/anatomyandphysiology/chapter/gonadal-and-placental-hormones/. 
  22. ↑ Yildiz, Bulent O.; Azziz, Ricardo (2007). "The adrenal and polycystic ovary syndrome". Reviews in Endocrine & Metabolic Disorders 8 (4): 331–342. doi:10.1007/s11154-007-9054-0. ISSN 1389-9155. PMID 17932770. 
  23. ↑ Abitbol, Leah; Zborovski, Stephen; Palmert, Mark R. (2016-07-19). "Evaluation of delayed puberty: what diagnostic tests should be performed in the seemingly otherwise well adolescent?". Archives of Disease in Childhood 101 (8): 767–771. doi:10.1136/archdischild-2015-310375. ISSN 1468-2044. PMID 27190100. 
  24. ↑ "Swyer syndrome" (in en-US). https://rarediseases.org/rare-diseases/swyer-syndrome/. 
  25. ↑ King, Thomas F. J.; Conway, Gerard S. (2014). "Swyer syndrome". Current Opinion in Endocrinology, Diabetes, and Obesity 21 (6): 504–510. doi:10.1097/MED.0000000000000113. ISSN 1752-2978. PMID 25314337. 
  26. ↑ Zieliñska, Dorota; Zajaczek, Stanislaw; Rzepka-Górska, Izabella (2007-05-29). "Tumors of dysgenetic gonads in Swyer syndrome". Journal of Pediatric Surgery 42 (10): 1721–1724. doi:10.1016/j.jpedsurg.2007.05.029. ISSN 1531-5037. PMID 17923202. 
  27. ↑ Gottlieb, Bruce; Trifiro, Mark A. (1993), Adam, Margaret P.; Everman, David B.; Mirzaa, Ghayda M. et al., eds., "Androgen Insensitivity Syndrome", GeneReviews® (Seattle, Washington: University of Washington, Seattle), PMID 20301602, https://www.ncbi.nlm.nih.gov/books/NBK1429/, retrieved 2023-01-20 
  28. ↑ Witchel, Selma Feldman (April 2018). "Disorders of Sex Development". Best Practice & Research. Clinical Obstetrics & Gynaecology 48: 90–102. doi:10.1016/j.bpobgyn.2017.11.005. ISSN 1521-6934. PMID 29503125. 
  29. ↑ "Familial Swyer syndrome: a rare genetic entity". Gynecol. Endocrinol. 34 (5): 389–393. May 2018. doi:10.1080/09513590.2017.1393662. PMID 29069951. 
  30. ↑ "Swyer syndrome" (in en-US). https://rarediseases.org/rare-diseases/swyer-syndrome/. 
  31. ↑ "Mami Y Yo y Mi Gallito, by Director Arisleyda Dilone – Intersex Campaign for Equality". https://www.intersexequality.com/mami-y-yo-y-mi-gallito-by-arisleyda-dilute/. 
  32. ↑ Kantola, Iida (27 October 2023). "Sara Forsberg kertoo olevansa intersukupuolinen" (in Finnish). Ilta-Sanomat. https://www.is.fi/viihde/art-2000009951725.html. 

Further reading

Classification

Template:Congenital malformations of genital organs and urinary system Template:Extracellular ligand disorders



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