Biology:ZEB1

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.[1][2][3]

ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.[3][2] ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain.[4] The structure of the homeodomain is shown on the right.

Clinical significance

Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. ZEB1 downregulates E-cadherin and induces epithelial to mesenchymal transition in breast and other carcinomas[5] A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.[6] Overexpression of ZEB1 has been identified as a potential risk factor for recurrence and poor prognosis in several types of cancers.[7]

References

  1. "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics 14 (1): 194–6. September 1992. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828. 
  2. 2.0 2.1 "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science 254 (5039): 1791–4. December 1991. doi:10.1126/science.1840704. PMID 1840704. Bibcode1991Sci...254.1791W. 
  3. 3.0 3.1 "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6935. 
  4. "Homeodomain proteins: an update". Chromosoma 125 (3): 497–521. July 2016. doi:10.1007/s00412-015-0543-8. PMID 26464018. 
  5. "DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells". Oncogene 24 (14): 2375–85. March 2005. doi:10.1038/sj.onc.1208429. PMID 15674322. 
  6. "Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1". Laboratory Investigation; A Journal of Technical Methods and Pathology 94 (4): 362–70. April 2014. doi:10.1038/labinvest.2013.153. PMID 24468793. 
  7. "ZEB1: Catalyst of immune escape during tumor metastasis". Biomed Pharmacother 153: 113490. September 2022. doi:10.1016/j.biopha.2022.113490. PMID 36076506. 

Further reading

External links