Biology:POU4F3
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Short description: Protein-coding gene in the species Homo sapiens
Generic protein structure example |
POU domain, class 4, transcription factor 3 is a protein that in humans is encoded by the POU4F3 gene.[1][2] It's a member of BRN-3 group, also known as POU family class 4.
Nomenclature
DFNA15 refers to a type of nonsyndromic deafness, with autosomal dominant inheritance.
References
- ↑ "Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans". Science 279 (5358): 1950–4. Apr 1998. doi:10.1126/science.279.5358.1950. PMID 9506947. Bibcode: 1998Sci...279.1950V.
- ↑ "Entrez Gene: POU4F3 POU domain, class 4, transcription factor 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5459.
Further reading
In Vivo Interplay between p27Kip1, GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice
- "Identification and functional analysis of common sequence variants in the DFNA15 gene, Brn-3c.". Gene 400 (1–2): 89–97. 2017. doi:10.1016/j.gene.2007.05.023. PMID 17611044. http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30390-X.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity". Biochem. Biophys. Res. Commun. 324 (1): 372–81. 2004. doi:10.1016/j.bbrc.2004.09.074. PMID 15465029.
- "The DFNA15 Deafness Mutation Affects POU4F3 Protein Stability, Localization, and Transcriptional Activity". Mol. Cell. Biol. 23 (22): 7957–64. 2003. doi:10.1128/MCB.23.22.7957-7964.2003. PMID 14585957.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma". Int. J. Cancer 101 (2): 103–10. 2002. doi:10.1002/ijc.10554. PMID 12209986.
- "Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development". Nature 381 (6583): 603–6. 1996. doi:10.1038/381603a0. PMID 8637595. Bibcode: 1996Natur.381..603E.
- "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons". J. Neurosci. 15 (7 Pt 1): 4762–85. 1995. doi:10.1523/JNEUROSCI.15-07-04762.1995. PMID 7623109.
External links
- POU4F3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Original source: https://en.wikipedia.org/wiki/POU4F3.
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