Biology:dnaN
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| DNA polymerase III subunit beta | |||||||
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| Identifiers | |||||||
| Organism | |||||||
| Symbol | dnaN | ||||||
| Entrez | 948218 | ||||||
| PDB | 1MMI (ECOD) | ||||||
| RefSeq (Prot) | NP_418156 | ||||||
| UniProt | P0A988 | ||||||
| Other data | |||||||
| EC number | 2.7.7.7 | ||||||
| Chromosome | MG1655: 3.88 - 3.88 Mb | ||||||
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dnaN is the gene that codes for the DNA clamp (also known as β sliding clamp) of DNA polymerase III in prokaryotes.[2][3] The β clamp physically locks Pol III onto a DNA strand during replication to help increase its processivity.[4] The eukaryotic equivalent to the β clamp is PCNA.
See also
- Beta clamp
References
- ↑ PDB: 1MMI; "Flexibility revealed by the 1.85 Å crystal structure of the beta sliding-clamp subunit of Escherichia coli DNA polymerase III". Acta Crystallogr. D 59 (Pt 7): 1192–9. July 2003. doi:10.1107/S0907444903009958. PMID 12832762. http://espace.library.uq.edu.au/view/UQ:39327/UQ39327_OA.pdf.
- ↑ "Structural analysis of the dnaA and dnaN genes of Escherichia coli". Gene 28 (2): 159–70. May 1984. doi:10.1016/0378-1119(84)90253-1. PMID 6234204.
- ↑ "Transcriptional organization of the dnaN and recF genes of Escherichia coli K-12". J. Biol. Chem. 263 (24): 12109–14. August 1988. PMID 2841344.
- ↑ "Mechanism of the sliding beta-clamp of DNA polymerase III holoenzyme". J. Biol. Chem. 266 (17): 11328–34. June 1991. PMID 2040637. http://www.jbc.org/content/266/17/11328.abstract.
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