Biology:Suppressor of cytokine signaling 1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene.[1][2] SOCS1 orthologs[3] have been identified in several mammals for which complete genome data are available.
Function
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), GM-CSF, and interferon-gamma (IFN-γ). The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-γ action, which is required for normal postnatal growth and survival.[4]
Several recent viral studies have shown that viral genes, such as Tax gene product (Tax), encoded by HTLV-1, could hijack SOCS1 to inhibit host antiviral pathways, as a strategy to evade host immunity.[5]
Interactions
The suppressor of cytokine signaling 1 has been shown to interact with:
- Tax,[5]
- CD117,[6]
- Colony stimulating factor 1 receptor[7]
- Growth hormone receptor,[8]
- IRS2,[9]
- Janus kinase 2,[10][11][12][13][14][15] and
- TEC.[16]
See also
References
- ↑ "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors". The EMBO Journal 14 (12): 2816–26. June 1995. doi:10.1002/j.1460-2075.1995.tb07281.x. PMID 7796808.
- ↑ "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochemical and Biophysical Research Communications 237 (1): 79–83. August 1997. doi:10.1006/bbrc.1997.7080. PMID 9266833.
- ↑ "OrthoMaM phylogenetic marker: SOCS1 coding sequence". http://www.orthomam.univ-montp2.fr/orthomam/data/cds/detailMarkers/ENSG00000185338_SOCS1.xml.
- ↑ "Entrez Gene: SOCS1 suppressor of cytokine signaling 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8651.
- ↑ 5.0 5.1 "Human T cell leukemia virus type 1 Tax inhibits innate antiviral signaling via NF-kappaB-dependent induction of SOCS1". Journal of Virology 85 (14): 6955–62. July 2011. doi:10.1128/JVI.00007-11. PMID 21593151.
- ↑ "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation". The EMBO Journal 18 (4): 904–15. February 1999. doi:10.1093/emboj/18.4.904. PMID 10022833.
- ↑ "Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal". The Journal of Biological Chemistry 276 (25): 22133–9. June 2001. doi:10.1074/jbc.M101878200. PMID 11297560.
- ↑ "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms". The Journal of Biological Chemistry 274 (50): 35553–61. December 1999. doi:10.1074/jbc.274.50.35553. PMID 10585430.
- ↑ "SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2". The Journal of Biological Chemistry 277 (44): 42394–8. November 2002. doi:10.1074/jbc.C200444200. PMID 12228220.
- ↑ "The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop". The EMBO Journal 18 (5): 1309–20. March 1999. doi:10.1093/emboj/18.5.1309. PMID 10064597.
- ↑ "Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor". Endocrinology 142 (12): 5286–93. December 2001. doi:10.1210/endo.142.12.8549. PMID 11713228.
- ↑ "A new protein containing an SH2 domain that inhibits JAK kinases". Nature 387 (6636): 921–4. June 1997. doi:10.1038/43213. PMID 9202126. Bibcode: 1997Natur.387..921E.
- ↑ "Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling". The Journal of Biological Chemistry 274 (35): 24497–502. August 1999. doi:10.1074/jbc.274.35.24497. PMID 10455112.
- ↑ "Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1". Molecular and Cellular Biology 22 (10): 3316–26. May 2002. doi:10.1128/mcb.22.10.3316-3326.2002. PMID 11971965.
- ↑ "Cloning and characterization of novel CIS family genes". Biochemical and Biophysical Research Communications 239 (2): 439–46. October 1997. doi:10.1006/bbrc.1997.7484. PMID 9344848.
- ↑ "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". The Journal of Biological Chemistry 272 (43): 27178–82. October 1997. doi:10.1074/jbc.272.43.27178. PMID 9341160.
Further reading
- "SOCS proteins: negative regulators of cytokine signaling". Stem Cells 19 (5): 378–87. 2001. doi:10.1634/stemcells.19-5-378. PMID 11553846.
- "Cytokine signaling in the brain: putting a SOCS in it?". Journal of Neuroscience Research 67 (4): 423–7. February 2002. doi:10.1002/jnr.10145. PMID 11835308.
- "The SOCS box: a tale of destruction and degradation". Trends in Biochemical Sciences 27 (5): 235–41. May 2002. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
- "A family of cytokine-inducible inhibitors of signalling". Nature 387 (6636): 917–21. June 1997. doi:10.1038/43206. PMID 9202125. Bibcode: 1997Natur.387..917S.
- "A new protein containing an SH2 domain that inhibits JAK kinases". Nature 387 (6636): 921–4. June 1997. doi:10.1038/43213. PMID 9202126. Bibcode: 1997Natur.387..921E.
- "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor". The Journal of Biological Chemistry 273 (37): 24095–101. September 1998. doi:10.1074/jbc.273.37.24095. PMID 9727029.
- "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation". The EMBO Journal 18 (4): 904–15. February 1999. doi:10.1093/emboj/18.4.904. PMID 10022833.
- "The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation". Proceedings of the National Academy of Sciences of the United States of America 96 (5): 2071–6. March 1999. doi:10.1073/pnas.96.5.2071. PMID 10051596. Bibcode: 1999PNAS...96.2071Z.
- "The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop". The EMBO Journal 18 (5): 1309–20. March 1999. doi:10.1093/emboj/18.5.1309. PMID 10064597.
- "SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality". Cell 98 (5): 609–16. September 1999. doi:10.1016/S0092-8674(00)80048-3. PMID 10490100.
- "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively". Genomics 61 (1): 108–11. October 1999. doi:10.1006/geno.1999.5937. PMID 10512686.
- "Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway". Experimental Hematology 27 (10): 1542–7. October 1999. doi:10.1016/S0301-472X(99)00094-6. PMID 10517496.
- "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms". The Journal of Biological Chemistry 274 (50): 35553–61. December 1999. doi:10.1074/jbc.274.50.35553. PMID 10585430.
- "JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling". Blood 97 (1): 221–6. January 2001. doi:10.1182/blood.V97.1.221. PMID 11133764.
- "Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation". The Journal of Experimental Medicine 193 (2): 263–9. January 2001. doi:10.1084/jem.193.2.263. PMID 11208867.
- "Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal". The Journal of Biological Chemistry 276 (25): 22133–9. June 2001. doi:10.1074/jbc.M101878200. PMID 11297560.
- "Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance". The Journal of Biological Chemistry 276 (28): 25889–93. July 2001. doi:10.1074/jbc.M010579200. PMID 11342531.
- "Suppressor of cytokine signaling-3 antagonizes cAMP effects on proliferation and apoptosis and is expressed in human prostate cancer". The American Journal of Pathology 169 (6): 2199–208. December 2006. doi:10.2353/ajpath.2006.060171. PMID 17148681.
- "Suppressor of cytokine signaling (SOCS)-1 is expressed in human prostate cancer and exerts growth-inhibitory function through down-regulation of cyclins and cyclin-dependent kinases". The American Journal of Pathology 174 (5): 1921–30. May 2009. doi:10.2353/ajpath.2009.080751. PMID 19342366.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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