Biology:SOCS5
From HandWiki
 Generic protein structure example |
Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene.[1][2][3]
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.[3]
References
- ↑ "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. Dec 1998. doi:10.1093/dnares/5.3.169. PMID 9734811.
- ↑ "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res 11 (3): 422–35. Mar 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- ↑ 3.0 3.1 "Entrez Gene: SOCS5 suppressor of cytokine signaling 5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9655.
Further reading
- "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. 2002. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
- "Cytokine signaling in the brain: putting a SOCS in it?". J. Neurosci. Res. 67 (4): 423–7. 2002. doi:10.1002/jnr.10145. PMID 11835308.
- "SOCS proteins: negative regulators of cytokine signaling". Stem Cells 19 (5): 378–87. 2001. doi:10.1634/stemcells.19-5-378. PMID 11553846.
- "The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model". J. Immunol. 175 (8): 5489–97. 2005. doi:10.4049/jimmunol.175.8.5489. PMID 16210657.
- "Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling". J. Biol. Chem. 280 (8): 7038–48. 2005. doi:10.1074/jbc.M408575200. PMID 15590694.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling". J. Biol. Chem. 279 (13): 12249–59. 2004. doi:10.1074/jbc.M313381200. PMID 14707129.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13003–8. 2002. doi:10.1073/pnas.202477099. PMID 12242343. Bibcode: 2002PNAS...9913003S.
- "Cloning and expression of CIS6, chromosome assignment to 3p22 and 2p21 by in situ hybridization". Cytogenet. Cell Genet. 88 (1–2): 78–81. 2000. doi:10.1159/000015490. PMID 10773671.
- "Twenty proteins containing a C-terminal SOCS box form five structural classes". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 114–9. 1998. doi:10.1073/pnas.95.1.114. PMID 9419338. Bibcode: 1998PNAS...95..114H.
 |
