Biology:PIAS1
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E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.[1][2][3]
Function
This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.[3]
Interactions
PIAS1 has been shown to interact with:
- DNMT3A,[4]
- P53,[5][6]
- STAT1,[7]
- Small ubiquitin-related modifier 1,[5][8]
- Sp3 transcription factor,[9] and
- UBE2I.[5][8][9]
References
- ↑ "Inhibition of Stat1-mediated gene activation by PIAS1". Proc Natl Acad Sci U S A 95 (18): 10626–10631. September 1998. doi:10.1073/pnas.95.18.10626. PMID 9724754. Bibcode: 1998PNAS...9510626L.
- ↑ "Cloning and characterization of Gu/RH-II binding protein". Biochem Biophys Res Commun 234 (2): 335–340. July 1997. doi:10.1006/bbrc.1997.6642. PMID 9177271.
- ↑ 3.0 3.1 "Entrez Gene: PIAS1 protein inhibitor of activated STAT, 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8554.
- ↑ "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription". Nucleic Acids Res. 32 (2): 598–610. 2004. doi:10.1093/nar/gkh195. PMID 14752048.
- ↑ 5.0 5.1 5.2 "Involvement of PIAS1 in the sumoylation of tumor suppressor p53". Mol. Cell 8 (3): 713–8. September 2001. doi:10.1016/s1097-2765(01)00349-5. PMID 11583632.
- ↑ "MBP1: a novel mutant p53-specific protein partner with oncogenic properties". Oncogene 18 (24): 3608–16. June 1999. doi:10.1038/sj.onc.1202937. PMID 10380882.
- ↑ "Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction". Proc. Natl. Acad. Sci. U.S.A. 97 (10): 5267–72. May 2000. doi:10.1073/pnas.97.10.5267. PMID 10805787. Bibcode: 2000PNAS...97.5267L.
- ↑ 8.0 8.1 "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Res. 98 (1): 83–91. December 2003. doi:10.1016/j.virusres.2003.09.001. PMID 14609633.
- ↑ 9.0 9.1 "Transcription factor Sp3 is silenced through SUMO modification by PIAS1". EMBO J. 21 (19): 5206–15. October 2002. doi:10.1093/emboj/cdf510. PMID 12356736.
Further reading
- "Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis". Mol. Endocrinol. 14 (1): 14–26. 2000. doi:10.1210/mend.14.1.0408. PMID 10628744.
- "Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction". Proc. Natl. Acad. Sci. U.S.A. 97 (10): 5267–5272. 2000. doi:10.1073/pnas.97.10.5267. PMID 10805787. Bibcode: 2000PNAS...97.5267L.
- "ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation". Mol. Endocrinol. 14 (12): 1986–2000. 2001. doi:10.1210/mend.14.12.0569. PMID 11117529.
- "Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells". Oncogene 20 (29): 3880–3887. 2001. doi:10.1038/sj.onc.1204489. PMID 11439351.
- "Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation". J. Biol. Chem. 276 (39): 36624–36631. 2001. doi:10.1074/jbc.M101085200. PMID 11451946.
- "Involvement of PIAS1 in the sumoylation of tumor suppressor p53". Mol. Cell 8 (3): 713–718. 2001. doi:10.1016/S1097-2765(01)00349-5. PMID 11583632.
- "LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1". Biochem. J. 359 (Pt 3): 485–96. 2001. doi:10.1042/0264-6021:3590485. PMID 11672422.
- "Activation of p53 by protein inhibitor of activated Stat1 (PIAS1)". J. Biol. Chem. 277 (10): 8255–8259. 2002. doi:10.1074/jbc.C200001200. PMID 11788578.
- "Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2872–2877. 2002. doi:10.1073/pnas.052559499. PMID 11867732. Bibcode: 2002PNAS...99.2872S.
- "Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators". J. Biol. Chem. 277 (19): 16993–17001. 2002. doi:10.1074/jbc.M109217200. PMID 11877418.
- "PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription". J. Biol. Chem. 277 (44): 41311–41317. 2003. doi:10.1074/jbc.M206741200. PMID 12177000.
- "SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling". J. Biol. Chem. 277 (45): 42981–42986. 2003. doi:10.1074/jbc.M208099200. PMID 12223491.
- "Transcription factor Sp3 is silenced through SUMO modification by PIAS1". EMBO J. 21 (19): 5206–5215. 2002. doi:10.1093/emboj/cdf510. PMID 12356736.
- "Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes". J. Biol. Chem. 277 (51): 50131–50136. 2003. doi:10.1074/jbc.M208319200. PMID 12393906.
- "PIAS proteins promote SUMO-1 conjugation to STAT1". Blood 102 (9): 3311–3313. 2004. doi:10.1182/blood-2002-12-3816. PMID 12855578.
- "PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation". J. Biol. Chem. 278 (48): 47434–47440. 2004. doi:10.1074/jbc.M308562200. PMID 14500712.
- "Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification". Mol. Endocrinol. 17 (12): 2529–2542. 2004. doi:10.1210/me.2003-0299. PMID 14500761.
- "Substantially reduced expression of PIAS1 is associated with colon cancer development". J Cancer Res Clin Oncol 135 (9): 1287–91. 2009. doi:10.1007/s00432-009-0570-z. PMID 19288270.
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