Biology:IRF7

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors.

Function

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.

The IRF7 pathway was shown to be silenced in some metastatic breast cancer cell lines, which may help the cells avoid the host immune response. Restoring IRF7 to these cell lines reduced metastases and increased host survival time in animal models.

The IRF7 gene and product were shown to be defective in a patient with severe susceptibility to H1N1 influenza, while susceptibility to other viral diseases such as CMV, RSV, and parainfluenza was unaffected.

Interactions

IRF7 has been shown to interact with IRF3. Also, IRF7 has been shown to interact with Aryl Hydrocarbon Receptor Interacting Protein (AIP), which is a negative regulator for the antiviral pathway.

See also

• Interferon regulatory factors

Further reading

• "IRF7: activation, regulation, modification and function". Genes and Immunity 12 (6): 399–414. September 2011. doi:10.1038/gene.2011.21. PMID 21490621. 
• "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth". Biochimie 80 (8–9): 651–8. 1999. doi:10.1016/S0300-9084(99)80018-2. PMID 9865487. 
• "Structure and function of IRF-7". Journal of Interferon & Cytokine Research 22 (1): 95–101. January 2002. doi:10.1089/107999002753452700. PMID 11846980. 
• "IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency". Molecular and Cellular Biology 17 (10): 5748–57. October 1997. doi:10.1128/MCB.17.10.5748. PMID 9315633. 
• "Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo". Molecular Cell 1 (4): 507–18. March 1998. doi:10.1016/S1097-2765(00)80051-9. PMID 9660935. 
• "Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes". The Journal of Biological Chemistry 273 (44): 29210–7. October 1998. doi:10.1074/jbc.273.44.29210. PMID 9786932. 
• "Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferon and silencing by hypermethylation". The Journal of Biological Chemistry 275 (41): 31805–12. October 2000. doi:10.1074/jbc.M005288200. PMID 10924517. 
• "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics 69 (2): 196–202. October 2000. doi:10.1006/geno.2000.6339. PMID 11031102. 
• "Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain". Molecular and Cellular Biology 20 (23): 8803–14. December 2000. doi:10.1128/MCB.20.23.8803-8814.2000. PMID 11073981. 
• "IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein". The Journal of Biological Chemistry 276 (12): 8951–7. March 2001. doi:10.1074/jbc.M008717200. PMID 11124948. 
• "Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3". Virology 280 (2): 273–82. February 2001. doi:10.1006/viro.2000.0782. PMID 11162841. 
• "Stimulation of IRF-7 gene expression by tumor necrosis factor alpha: requirement for NFkappa B transcription factor and gene accessibility". The Journal of Biological Chemistry 277 (19): 16592–8. May 2002. doi:10.1074/jbc.M111440200. PMID 11877397. 
• "Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription". Journal of Molecular Biology 316 (5): 1009–22. March 2002. doi:10.1006/jmbi.2001.5401. PMID 11884139. 
• "Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding". The Journal of Biological Chemistry 277 (51): 49417–21. December 2002. doi:10.1074/jbc.M207484200. PMID 12374802. 
• "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nature Medicine 9 (2): 191–7. February 2003. doi:10.1038/nm822. PMID 12539042. 
• "Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators". The Journal of Biological Chemistry 278 (18): 15495–504. May 2003. doi:10.1074/jbc.M212940200. PMID 12604599. 
• "Interferon regulatory factor 7 regulates expression of Epstein-Barr virus latent membrane protein 1: a regulatory circuit". Journal of Virology 77 (17): 9359–68. September 2003. doi:10.1128/JVI.77.17.9359-9368.2003. PMID 12915551. 
• "LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF". The Journal of Experimental Medicine 198 (7): 1043–55. October 2003. doi:10.1084/jem.20031023. PMID 14517278. 
• "The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes". Journal of Virology 78 (4): 1675–84. February 2004. doi:10.1128/JVI.78.4.1675-1684.2004. PMID 14747533. 

External links

• IRF7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.