Biology:HSPB7
 Generic protein structure example |
Heat Shock Protein Family B (small) member 7 (HSPB7) in humans is a protein encoded by a gene of the same name with four exons that is located on chromosome 1p36.13.[1],.[2] HSPB7 contains 170 amino acids and has a molecular weight of 18,611Da.[3] HSPB7 is a member of human small heat shock protein (HSPB) family, which contains eleven family members of chaperone proteins.[4] HSPB7 and its gene pair SRARP are located 5 kb apart on the opposite strands of chromosome 1p36.13.[5]
Expression and molecular function
HSPB7 is widely expressed throughout the body and its highest expression is observed in the cardiac tissue [4],.[6] HSPB protein family, including HSPB7, act protectively on aggregation of several proteins containing an extended polyglutamine (polyQ) stretch that are linked to a variety of neurodegenerative diseases.[7] Among these proteins, HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of chaperones.[7] In addition, HSPB7 protein contains a HSP20 domain and strongly interacts with the chaperone protein 14-3-3.[5] An interaction with the 14-3-3 protein is a common molecular feature between HSPB7 and SRARP proteins [5],[8]
Role in cardiomyopathy and Cancer
HSPB7 has cardiac protective functions and mutations in this gene leads to cardiomyopathies.[7] It has been suggested that HSPB7 cardioprotective function is mediated by facilitating sarcomeric proteostasis.[9] Furthermore, HSPB7 is widely inactivated in malignancies by copy-number loss and epigenetic silencing and the overexpression of this protein results in a tumor suppressor function in multiple cancer cell lines[5],.[10] The overexpression of HSPB7 and its gene pair SRARP lead to a reduction in the relative phosphorylation and/or expression of Akt and ERK in cancer cells.[5] In addition, it has been suggested that HSBP7 is regulated by p53 tumor suppressor in renal cell carcinoma.[10]
| Approved Symbol | HSPB7 |
|---|---|
| Approved Name | Heat shock protein family B (small) member 7 |
| HGNC ID | HGNC:5249 |
| Previous name | heat shock 27kD protein family, member 7 (cardiovascular) |
| Alias Symbols | cvHSP |
| Chromosome location | 1p36.13 |
| Ensembl | ENSG00000173641 |
| UniProt | Q9UBY9 |
| NCBI Gene | 27129 |
| RefSeq | NM_014424 |
| UCSC | uc001axo.2 |
| Protein Sequence | HSPB7 Protein Sequence (Ensembl) |
| Wikidata | Q18038659 |
| PubMed | HSPB7 PubMed References |
References
- ↑ "HSPB7". https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5249.
- ↑ "HSPB7 heat shock protein family B (small) member 7 [ Homo sapiens (human)"]. https://www.ncbi.nlm.nih.gov/gene/27129.
- ↑ "HSPB7_HUMAN". https://www.uniprot.org/uniprot/?query=hspb7&sort=score.
- ↑ 4.0 4.1 "HSPB7 is a SC35 speckle resident small heat shock protein". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1793 (8): 1343–53. August 2009. doi:10.1016/j.bbamcr.2009.05.005. PMID 19464326.
- ↑ 5.0 5.1 5.2 5.3 5.4 "SRARP and HSPB7 are epigenetically regulated gene pairs that function as tumor suppressors and predict clinical outcome in malignancies". Molecular Oncology 12 (5): 724–755. May 2018. doi:10.1002/1878-0261.12195. PMID 29577611.
- ↑ "HSPB7 is indispensable for heart development by modulating actin filament assembly". Proceedings of the National Academy of Sciences of the United States of America 114 (45): 11956–11961. November 2017. doi:10.1073/pnas.1713763114. PMID 29078393. Bibcode: 2017PNAS..11411956W.
- ↑ 7.0 7.1 7.2 "HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones". Human Molecular Genetics 19 (23): 4677–93. December 2010. doi:10.1093/hmg/ddq398. PMID 20843828.
- ↑ "C1orf64 is a novel androgen receptor target gene and coregulator that interacts with 14-3-3 protein in breast cancer". Oncotarget 8 (34): 57907–57933. August 2017. doi:10.18632/oncotarget.17826. PMID 28915724.
- ↑ "Hspb7 is a cardioprotective chaperone facilitating sarcomeric proteostasis". Developmental Biology 435 (1): 41–55. March 2018. doi:10.1016/j.ydbio.2018.01.005. PMID 29331499.
- ↑ 10.0 10.1 "Downregulation of the tumor suppressor HSPB7, involved in the p53 pathway, in renal cell carcinoma by hypermethylation". International Journal of Oncology 44 (5): 1490–8. May 2014. doi:10.3892/ijo.2014.2314. PMID 24585183.
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