Biology:2-acylglycerophosphocholine O-acyltransferase
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Short description: Class of enzymes
| 2-acylglycerophosphocholine O-acyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.62 | ||||||||
| CAS number | 64295-73-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 2-acylglycerophosphocholine O-acyltransferase (EC 2.3.1.62) is an enzyme that catalyzes the chemical reaction
- acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine [math]\displaystyle{ \rightleftharpoons }[/math] CoA + phosphatidylcholine
Thus, the two substrates of this enzyme are acyl-CoA and 2-acyl-sn-glycero-3-phosphocholine, whereas its two products are CoA and phosphatidylcholine.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase. Other names in common use include 2-acylglycerol-3-phosphorylcholine acyltransferase, and 2-acylglycerophosphocholine acyltransferase. This enzyme participates in glycerophospholipid metabolism.
References
- "Metabolism of glycerolipids. VI. Specificities of acyl coenzyme A:phospholipid acyltransferases". J. Biol. Chem. 240: 1905–1911. 1965. PMID 14299609.
- "The acylation of isomeric monoacyl phosphatidylcholines". Biochim. Biophys. Acta 152 (4): 694–703. 1968. doi:10.1016/0005-2760(68)90115-x. PMID 5660084.
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