Biology:Acid—CoA ligase (GDP-forming)
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Short description: Class of enzymes
| Acid—CoA ligase (GDP-forming) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 6.2.1.10 | ||||||||
| CAS number | 37318-59-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, an acid—CoA ligase (GDP-forming) (EC 6.2.1.10) is an enzyme that catalyzes the chemical reaction
- GTP + an acid + CoA [math]\displaystyle{ \rightleftharpoons }[/math] GDP + phosphate + acyl-CoA
The 3 substrates of this enzyme are GTP, acid, and CoA, whereas its 3 products are GDP, phosphate, and acyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acid:CoA ligase (GDP-forming). Other names in common use include acyl-CoA synthetase (GDP-forming), and acyl coenzyme A synthetase (guanosine diphosphate forming).
References
- "Activation of fatty acids by a guanosine triphosphate-specific thiokinase from liver mitochondria" (PDF). The Journal of Biological Chemistry 239 (6): 1694–9. June 1964. PMID 14213337. http://www.jbc.org/content/239/6/1694.full.pdf.
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