Biology:CDP-acylglycerol O-arachidonoyltransferase
| CDP-acylglycerol O-arachidonoyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.3.1.70 | ||||||||
| CAS number | 70771-22-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a CDP-acylglycerol O-arachidonoyltransferase (EC 2.3.1.70) was an enzyme construed to catalyze the chemical reaction
- arachidonoyl-CoA + CDP-acylglycerol [math]\displaystyle{ \rightleftharpoons }[/math] CoA + CDP-diacylglycerol
When discovered in 1979, the two substrates of this enzyme were believed to be arachidonoyl-CoA and CDP-acylglycerol, whereas its two products were CoA and CDP-diacylglycerol.[1]
Such enzyme were describes as transferases, specifically acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class was arachidonoyl-CoA:CDP-acylglycerol O-arachidonoyltransferase. Other names also found are CDP-acylglycerol O-arachidonyltransferase, and arachidonyl-CoA:CDP-acylglycerol O-arachidonyltransferase. Such enzyme was presumably participating in glycerophospholipid metabolism.
However, no CDP-acylglycerol O-arachidonoyltransferase has been characterized, the reaction demonstrated in 1979 by Thompson and MacDonald was not reproducible. In 1983, W. Thomson retracted his discovery explaining possible contamination of their batch of liponucleotides.[2]
References
- ↑ Thompson, W.; MacDonald, G. (1979-05-10). "Isolation of a specific arachidonoyl coenzyme A: cytidine diphosphate monoacylglycerol acyltransferase". The Journal of Biological Chemistry 254 (9): 3311–3314. ISSN 0021-9258. PMID 429352. https://pubmed.ncbi.nlm.nih.gov/429352.
- ↑ Thompson, W.; Zuk, R. T. (1983-08-25). "Acylation of CDP-monoacylglycerol cannot be confirmed". The Journal of Biological Chemistry 258 (16): 9623. ISSN 0021-9258. PMID 6885763. https://pubmed.ncbi.nlm.nih.gov/6885763.
- "Isolation of a specific arachidonoyl coenzyme A: cytidine diphosphate monoacylglycerol acyltransferase". J. Biol. Chem. 254 (9): 3311–4. 1979. PMID 429352.
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