Biology:ADP-sugar diphosphatase
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Short description: Class of enzymes
| ADP-sugar diphosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.6.1.21 | ||||||||
| CAS number | 37289-32-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an ADP-sugar diphosphatase (EC 3.6.1.21) is an enzyme that catalyzes the chemical reaction
- ADP-sugar + H2O [math]\displaystyle{ \rightleftharpoons }[/math] AMP + alpha-D-aldose 1-phosphate
Thus, the two substrates of this enzyme are ADP-sugar and H2O, whereas its two products are AMP and alpha-D-aldose 1-phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is ADP-sugar sugarphosphohydrolase. Other names in common use include ADP-sugar pyrophosphatase, and adenosine diphosphosugar pyrophosphatase. This enzyme participates in 3 metabolic pathways: fructose and mannose metabolism, purine metabolism, and starch and sucrose metabolism.
References
- "A pyrophosphatase from mammalian tissues specific for derivatives of ADP". Biochim. Biophys. Acta 167 (1): 199–201. 1968. doi:10.1016/0005-2744(68)90294-5. PMID 5686292.
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