Biology:3-ethylmalate synthase
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Short description: Class of enzymes
| 3-ethylmalate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.3.7 | ||||||||
| CAS number | 9024-01-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a 3-ethylmalate synthase (EC 2.3.3.7) is an enzyme that catalyzes the chemical reaction
- butanoyl-CoA + H2O + glyoxylate [math]\displaystyle{ \rightleftharpoons }[/math] 3-ethylmalate + CoA
The 3 substrates of this enzyme are butanoyl-CoA, H2O, and glyoxylate, whereas its two products are 3-ethylmalate and CoA.
This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is butanoyl-CoA:glyoxylate C-butanoyltransferase (thioester-hydrolysing, 1-carboxypropyl-forming). Other names in common use include 2-ethyl-3-hydroxybutanedioate synthase, and 3-ethylmalate glyoxylate-lyase (CoA-butanoylating). This enzyme participates in glyoxylate and dicarboxylate metabolism.
References
- "Phosphoglucose isomerase of green gram (Phaseolus radiatus)". Arch. Biochem. Biophys. 62 (1): 91–6. 1956. doi:10.1016/0003-9861(56)90091-1. PMID 13314642.
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