Biology:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase
| N-acetylneuraminate 7-O(or 9-O)-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.45 | ||||||||
| CAS number | 9054-50-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a N-acetylneuraminate 7-O(or 9-O)-acetyltransferase (EC 2.3.1.45) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + N-acetylneuraminate [math]\displaystyle{ \rightleftharpoons }[/math] CoA + N-acetyl-7-O(or 9-O)-acetylneuraminate
Thus, the two substrates of this enzyme are acetyl-CoA and N-acetylneuraminate, whereas its 3 products are CoA, N-acetyl-7-O-acetylneuraminate, and N-acetyl-9-O-acetylneuraminate.
Nomenclature
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase. Other names in common use include N-acetylneuraminate 7(8)-O-acetyltransferase, sialate O-acetyltransferase, N-acetylneuraminate 7,8-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase, glycoprotein 7(9)-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase, N-acetylneuraminate O7-(or O9-)acetyltransferase, and acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase.
References
- "[Biosynthesis of N-acetyl-O-acetylneuraminic acids. I. Incorporation of (14C) acetate into sections of the submaxillary salivary gland of ox and horse]". Hoppe-Seyler's Zeitschrift für Physiologische Chemie 351 (5): 595–602. May 1970. PMID 5446640.
- "[Biosynthesis of N-acetyl-O-acetylneuraminic acids. II. Substrate and intracellular localization of bovine acetyl-coenzyme A: N-acetylneuraminate-7- and 8-O-acetyltransferase]". Hoppe-Seyler's Zeitschrift für Physiologische Chemie 351 (6): 749–58. June 1970. doi:10.1515/bchm2.1970.351.1.749. PMID 5425947.
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