Biology:23S rRNA pseudouridine746 synthase

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Short description: Enzyme
23S rRNA pseudouridine746 synthase
Identifiers
EC number5.4.99.29
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

23S rRNA pseudouridine746 synthase (EC 5.4.99.29, RluA, 23S RNA PSI746 synthase, 23S rRNA pseudouridine synthase, pseudouridine synthase RluA) is an enzyme with systematic name 23S rRNA-uridine746 uracil mutase.[1][2][3] This enzyme catalyses the following chemical reaction

23S rRNA uridine746 [math]\displaystyle{ \rightleftharpoons }[/math] 23S rRNA pseudouridine746

RluA is the only protein responsible for the in vivo formation of 23S RNA pseudouridine746.

References

  1. "Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure". Molecular Cell 24 (4): 535–45. November 2006. doi:10.1016/j.molcel.2006.09.017. PMID 17188032. 
  2. "Functional effect of deletion and mutation of the Escherichia coli ribosomal RNA and tRNA pseudouridine synthase RluA". The Journal of Biological Chemistry 274 (27): 18880–6. July 1999. doi:10.1074/jbc.274.27.18880. PMID 10383384. 
  3. "A dual-specificity pseudouridine synthase: an Escherichia coli synthase purified and cloned on the basis of its specificity for psi 746 in 23S RNA is also specific for psi 32 in tRNA(phe)". RNA 1 (4): 437–48. June 1995. PMID 7493321. 

External links