Biology:Platelet-activating factor acetyltransferase
From HandWiki
Short description: Class of enzymes
| platelet-activating factor acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.149 | ||||||||
| CAS number | 9012-30-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a platelet-activating factor acetyltransferase (EC 2.3.1.149) is an enzyme that catalyzes the chemical reaction
- 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid [math]\displaystyle{ \rightleftharpoons }[/math] 1-organyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-acetyl-sn-glycero-3-phospholipid
Thus, the two substrates of this enzyme are 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine and 1-organyl-2-lyso-sn-glycero-3-phospholipid, whereas its two products are 1-organyl-2-lyso-sn-glycero-3-phosphocholine and 1-alkyl-2-acetyl-sn-glycero-3-phospholipid.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glyce ro-3-phospholipid acetyltransferase. This enzyme is also called PAF acetyltransferase.
References
- "A novel CoA-independent transacetylase produces the ethanolamine plasmalogen and acyl analogs of platelet-activating factor (PAF) with PAF as the acetate donor in HL-60 cells". J. Biol. Chem. 267 (28): 19992–20001. 1992. PMID 1400315.
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