Biology:Acyl-(acyl-carrier-protein)—phospholipid O-acyltransferase
| acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.3.1.40 | ||||||||
| CAS number | 37257-18-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase (EC 2.3.1.40) is an enzyme that catalyzes the chemical reaction
- acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine [math]\displaystyle{ \rightleftharpoons }[/math] [acyl-carrier protein] + O-(1,2-diacyl-sn-glycero-3-phospho)ethanolamine
Thus, the two substrates of this enzyme are acyl-acyl-carrier protein and O-(2-acyl-sn-glycero-3-phospho)ethanolamine, whereas its two products are acyl-carrier protein and O-(1,2-diacyl-sn-glycero-3-phospho)ethanolamine.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-[acyl-carrier protein]:O-(2-acyl-sn-glycero-3-phospho)ethanolamine O-acyltransferase. Other names in common use include acyl-[acyl-carrier, protein]:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine, and O-acyltransferase. This enzyme participates in glycerophospholipid metabolism.
References
- "The incorporation of beta-hydroxy fatty acids into a phospholipid of Escherichia coli B". J. Biol. Chem. 244 (24): 6605–16. 1969. PMID 4902888.
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