Biology:Patchoulol synthase

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Short description: Class of enzymes
Patchoulol synthase
Identifiers
EC number4.2.3.70
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Patchoulol synthase (EC 4.2.3.70) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (patchoulol-forming).[1][2][3] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] patchoulol + diphosphate

References

  1. "Biosynthesis of the sesquiterpene patchoulol from farnesyl pyrophosphate in leaf extracts of Pogostemon cablin (patchouli): mechanistic considerations". Archives of Biochemistry and Biophysics 256 (1): 56–68. July 1987. doi:10.1016/0003-9861(87)90425-5. PMID 3038029. 
  2. "Purification and characterization of the sesquiterpene cyclase patchoulol synthase from Pogostemon cablin". Archives of Biochemistry and Biophysics 282 (1): 58–64. October 1990. doi:10.1016/0003-9861(90)90086-e. PMID 2171435. 
  3. "Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-2H1]farnesyl diphosphate catalyzed by recombinant patchoulol synthase". Journal of the American Chemical Society 132 (9): 2998–3008. March 2010. doi:10.1021/ja909251r. PMID 20148554. 

External links