Biology:1-acylglycerol-3-phosphate O-acyltransferase
1-acylglycerol-3-phosphate O-acyltransferase | |||||||||
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Identifiers | |||||||||
EC number | 2.3.1.51 | ||||||||
CAS number | 51901-16-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) is an enzyme that catalyzes the chemical reaction
- acyl-CoA + 1-acyl-sn-glycerol 3-phosphate [math]\displaystyle{ \rightleftharpoons }[/math] CoA + 1,2-diacyl-sn-glycerol 3-phosphate
Thus, the two substrates of this enzyme are acyl-CoA and 1-acyl-sn-glycerol 3-phosphate, whereas its two products are CoA and 1,2-diacyl-sn-glycerol 3-phosphate.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase. Other names in common use include 1-acyl-sn-glycero-3-phosphate acyltransferase, 1-acyl-sn-glycerol 3-phosphate acyltransferase, 1-acylglycero-3-phosphate acyltransferase, 1-acylglycerolphosphate acyltransferase, 1-acylglycerophosphate acyltransferase, and lysophosphatidic acid-acyltransferase. This enzyme participates in 3 metabolic pathways: glycerolipid metabolism, glycerophospholipid metabolism, and ether lipid metabolism.
References
- "Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts". Eur. J. Biochem. 129 (3): 629–636. 1983. doi:10.1111/j.1432-1033.1983.tb07096.x. PMID 6825679.
- "Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine". Biochim. Biophys. Acta 152 (3): 645–8. 1968. doi:10.1016/0005-2760(68)90109-4. PMID 5661029. https://deepblue.lib.umich.edu/bitstream/2027.42/33183/1/0000571.pdf.
- "Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes". Eur. J. Biochem. 38 (1): 25–31. 1973. doi:10.1111/j.1432-1033.1973.tb03028.x. PMID 4774123.
![]() | Original source: https://en.wikipedia.org/wiki/1-acylglycerol-3-phosphate O-acyltransferase.
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