Biology:Retinol O-fatty-acyltransferase
From HandWiki
| retinol O-fatty-acyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.3.1.76 | ||||||||
| CAS number | 81295-48-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a retinol O-fatty-acyltransferase (EC 2.3.1.76) is an enzyme that catalyzes the chemical reaction
- acyl-CoA + retinol [math]\displaystyle{ \rightleftharpoons }[/math] CoA + retinyl ester
Thus, the two substrates of this enzyme are acyl-CoA and retinol, whereas its two products are CoA and retinyl ester.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:retinol O-acyltransferase. Other names in common use include retinol acyltransferase, and retinol fatty-acyltransferase. This enzyme participates in retinol metabolism.
References
- "Retinol esterification by microsomes from the mucosa of human small intestine. Evidence for acyl-Coenzyme A retinol acyltransferase activity". J. Clin. Invest. 71 (3): 747–53. 1983. doi:10.1172/JCI110822. PMID 6826734.
- Ross AC (1982). "Retinol esterification by rat liver microsomes. Evidence for a fatty acyl coenzyme A: retinol acyltransferase". J. Biol. Chem. 257 (5): 2453–9. PMID 7061433.
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