Biology:ATP1A4
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Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.[1][2][3]
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]
References
- ↑ "A detailed multipoint gene map of chromosome 1q". Genomics 8 (1): 13–21. May 1991. doi:10.1016/0888-7543(90)90220-O. PMID 1981991.
- ↑ "Multiple genes encode the human Na+,K+-ATPase catalytic subunit". Proc Natl Acad Sci U S A 84 (12): 4039–43. Jul 1987. doi:10.1073/pnas.84.12.4039. PMID 3035563. Bibcode: 1987PNAS...84.4039S.
- ↑ 3.0 3.1 "Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=480.
External links
- Human ATP1A1 genome location and ATP1A1 gene details page in the UCSC Genome Browser.
- Human ATP1A4 genome location and ATP1A4 gene details page in the UCSC Genome Browser.
Further reading
- "Molecular genetics of Na, K-ATPase". Prog. Nucleic Acid Res. Mol. Biol.. Progress in Nucleic Acid Research and Molecular Biology 38: 37–89. 1990. doi:10.1016/S0079-6603(08)60708-4. ISBN 978-0-12-540038-1. PMID 2158121.
- "Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism". FEBS Lett. 221 (1): 129–33. 1987. doi:10.1016/0014-5793(87)80366-6. PMID 2887455.
- "The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit". FEBS Lett. 217 (2): 275–8. 1987. doi:10.1016/0014-5793(87)80677-4. PMID 3036582.
- "A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12952–6. 1995. doi:10.1073/pnas.91.26.12952. PMID 7809153.
- "Characterization of the fourth alpha isoform of the Na, K-ATPase". J. Membr. Biol. 169 (1): 39–44. 1999. doi:10.1007/PL00005899. PMID 10227850.
- "Sperm motility is dependent on a unique isoform of the Na, K-ATPase". J. Biol. Chem. 275 (27): 20693–9. 2000. doi:10.1074/jbc.M002323200. PMID 10764792.
- "Roles of the Na, K-ATPase alpha4 isoform and the Na+/H+ exchanger in sperm motility". Mol. Reprod. Dev. 62 (3): 348–56. 2003. doi:10.1002/mrd.90002. PMID 12112599.
- "Physical mapping and characterization of the human Na, K-ATPase isoform, ATP1A4". Gene 292 (1–2): 151–66. 2002. doi:10.1016/S0378-1119(02)00647-9. PMID 12119109.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Functional roles of the alpha isoforms of the Na, K-ATPase". Ann. N. Y. Acad. Sci. 986 (1): 354–9. 2003. doi:10.1111/j.1749-6632.2003.tb07214.x. PMID 12763850. Bibcode: 2003NYASA.986..354L.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The human Na, K-ATPase alpha 4 isoform is an ouabain-sensitive alpha isoform that is expressed in sperm". Mol. Reprod. Dev. 73 (1): 101–15. 2006. doi:10.1002/mrd.20383. PMID 16175638.
- "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
- "The transcription factor CREMtau and cAMP regulate promoter activity of the Na, K-ATPase alpha4 isoform". Mol. Reprod. Dev. 73 (11): 1435–47. 2006. doi:10.1002/mrd.20518. PMID 16894555.
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