Biology:2-deoxy-scyllo-inosose synthase
From HandWiki
Short description: Enzyme
| 2-deoxy-scyllo-inosose synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.3.124 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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2-deoxy-scyllo-Inosose synthase (EC 4.2.3.124, btrC (gene), neoC (gene), kanC (gene)) is an enzyme with systematic name D-glucose-6-phosphate phosphate-lyase (2-deoxy-scyllo-inosose-forming).[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- D-glucose 6-phosphate [math]\displaystyle{ \rightleftharpoons }[/math] 2-deoxy-L-scyllo-inosose + phosphate
This enzyme requires Co2+.
References
- ↑ "Kinetic isotope effect and reaction mechanism of 2-deoxy-scyllo-inosose synthase derived from butirosin-producing Bacillus circulans". The Journal of Antibiotics 50 (5): 424–8. May 1997. doi:10.7164/antibiotics.50.424. PMID 9207913.
- ↑ "Purification and characterization of 2-deoxy-scyllo-inosose synthase derived from Bacillus circulans. A crucial carbocyclization enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics". The Journal of Antibiotics 52 (2): 81–8. February 1999. doi:10.7164/antibiotics.52.81. PMID 10344560.
- ↑ "Molecular cloning of the gene for the key carbocycle-forming enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics and its comparison with dehydroquinate synthase". The Journal of Antibiotics 52 (6): 559–71. June 1999. doi:10.7164/antibiotics.52.559. PMID 10470681.
- ↑ "Stereospecificity of hydride transfer in NAD+-catalyzed 2-deoxy-scyllo-inosose synthase, the key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics". Bioorganic Chemistry 33 (2): 82–9. April 2005. doi:10.1016/j.bioorg.2004.09.002. PMID 15788164.
- ↑ "Expression of 2-deoxy-scyllo-inosose synthase (kanA) from kanamycin gene cluster in Streptomyces lividans". Biotechnology Letters 27 (7): 465–70. April 2005. doi:10.1007/s10529-005-2222-y. PMID 15928851.
- ↑ "Significance of the 20-kDa subunit of heterodimeric 2-deoxy-scyllo-inosose synthase for the biosynthesis of butirosin antibiotics in Bacillus circulans". Bioscience, Biotechnology, and Biochemistry 66 (7): 1538–45. July 2002. doi:10.1271/bbb.66.1538. PMID 12224638.
- ↑ "Roles of a 20 kDa protein associated with a carbocycle-forming enzyme involved in aminoglycoside biosynthesis in primary and secondary metabolism". Bioscience, Biotechnology, and Biochemistry 74 (6): 1215–9. 2010. doi:10.1271/bbb.90961. PMID 20530911.
External links
- 2-deoxy-scyllo-inosose+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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