Biology:2-methyleneglutarate mutase
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Short description: Class of enzymes
| 2-methyleneglutarate mutase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.4.99.4 | ||||||||
| CAS number | 9059-10-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 2-methyleneglutarate mutase (EC 5.4.99.4) is an enzyme that catalyzes the chemical reaction
- 2-methyleneglutarate [math]\displaystyle{ \rightleftharpoons }[/math] 2-methylene-3-methylsuccinate
Hence, this enzyme has one substrate, 2-methyleneglutarate, and one product, 2-methylene-3-methylsuccinate.
This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is 2-methyleneglutarate carboxy-methylenemethylmutase. This enzyme is also called alpha-methyleneglutarate mutase. This enzyme participates in c5-branched dibasic acid metabolism. It employs one cofactor, cobamide.
References
- "Nicotinic acid metabolism. V. A cobamide coenzyme-dependent conversion of alpha-methyleneglutaric acid to dimethylmaleic acid". Proc. Natl. Acad. Sci. U.S.A. 65 (4): 978–84. 1970. doi:10.1073/pnas.65.4.978. PMID 5266166. Bibcode: 1970PNAS...65..978K.
- "Nicotinic acid metabolism. VI. Purification and properties of alpha-methyleneglutarate mutase (B 12-dependent) and methylitaconate isomerase". J. Biol. Chem. 246 (10): 3378–88. 1971. doi:10.1016/S0021-9258(18)62235-5. PMID 5574401.
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