Biology:3,5,7-Trioxododecanoyl-CoA synthase
From HandWiki
Short description: Class of enzymes
| 3,5,7-Trioxododecanoyl-CoA synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.206 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
3,5,7-Trioxododecanoyl-CoA synthase (EC 2.3.1.206, TKS) is an enzyme with systematic name malonyl-CoA:hexanoyl-CoA malonyltransferase (3,5,7-trioxododecanoyl-CoA-forming).[1][2] This enzyme catalyses the following chemical reaction
- 3 malonyl-CoA + hexanoyl-CoA [math]\displaystyle{ \rightleftharpoons }[/math] 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2
This polyketide synthase catalyse the first step in the cannabinoids biosynthetic pathway of the plant Cannabis sativa.
References
- ↑ "Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway". FEBS Letters 583 (12): 2061–6. June 2009. doi:10.1016/j.febslet.2009.05.024. PMID 19454282.
- ↑ "Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides". Proceedings of the National Academy of Sciences of the United States of America 109 (31): 12811–6. July 2012. doi:10.1073/pnas.1200330109. PMID 22802619. Bibcode: 2012PNAS..10912811G.
External links
- 3,5,7-trioxododecanoyl-CoA+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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