Biology:AKR1C1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Aldo-keto reductase family 1 member C1 is an enzyme that in humans is encoded by the AKR1C1 gene.[1][2] This multi-functional enzyme is involved in degrading progesterone and androgens, as well as producing the active neurosteroid 3alpha,5alpha-THDOC.[3] More generally, it can function as a 20α-hydroxysteroid dehydrogenase, and a 3α-hydroxysteroid dehydrogenase, among other functions.[3]
Superfamily of enzymes
This gene encodes a member of the aldo-keto reductase family which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity.
AKR1C family
The AKR1C1 gene shares high sequence identity with three other gene members that are clustered at chromosome 10p15-p14.[2]
References
- ↑ "cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase". Biochimica et Biophysica Acta (BBA) - Bioenergetics 1186 (1–2): 129–32. Jun 1994. doi:10.1016/0005-2728(94)90144-9. PMID 8011662.
- ↑ 2.0 2.1 "Entrez Gene: AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1645.
- ↑ 3.0 3.1 "Aldo-keto reductase family 1 member C1". UniProt consortium. https://www.uniprot.org/uniprotkb/Q04828/entry.
See also
External links
- Human AKR1C1 genome location and AKR1C1 gene details page in the UCSC Genome Browser.
- Human C9 genome location and C9 gene details page in the UCSC Genome Browser.
Further reading
- "Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics". The Journal of Biological Chemistry 269 (22): 15558–62. Jun 1994. doi:10.1016/S0021-9258(17)40716-2. PMID 7515059.
- "Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans". The Journal of Steroid Biochemistry and Molecular Biology 53 (1–6): 41–6. Jun 1995. doi:10.1016/0960-0760(95)00019-V. PMID 7626489.
- "Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization". Genomics 25 (2): 588–90. Jan 1995. doi:10.1016/0888-7543(95)80066-U. PMID 7789999.
- "Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding". The Journal of Biological Chemistry 269 (11): 8416–22. Mar 1994. doi:10.1016/S0021-9258(17)37210-1. PMID 8132567.
- "Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder". The Biochemical Journal 299 (2): 545–52. Apr 1994. doi:10.1042/bj2990545. PMID 8172617.
- "Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase". The Journal of Steroid Biochemistry and Molecular Biology 46 (6): 673–9. Dec 1993. doi:10.1016/0960-0760(93)90308-J. PMID 8274401.
- "cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family". The Journal of Biological Chemistry 268 (14): 10448–57. May 1993. doi:10.1016/S0021-9258(18)82220-7. PMID 8486699.
- "Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells". The Biochemical Journal 313 (2): 373–6. Jan 1996. doi:10.1042/bj3130373. PMID 8573067.
- "Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members". The Biochemical Journal 343 (2): 487–504. Oct 1999. doi:10.1042/bj3430487. PMID 10510318.
- "Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes". Genes to Cells 5 (2): 111–25. Feb 2000. doi:10.1046/j.1365-2443.2000.00310.x. PMID 10672042.
- "Characterization of a human 20alpha-hydroxysteroid dehydrogenase". Journal of Molecular Endocrinology 25 (2): 221–8. Oct 2000. doi:10.1677/jme.0.0250221. PMID 11013348.
- "Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution". The Journal of Biological Chemistry 276 (45): 42091–8. Nov 2001. doi:10.1074/jbc.M105610200. PMID 11514561.
- "Expression of dihydrodiol dehydrogenase in the resected stage I non-small cell lung cancer". Oncology Reports 9 (3): 515–9. 2002. doi:10.3892/or.9.3.515. PMID 11956619.
- "Reduction of dihydrodiol dehydrogenase expression in resected hepatocellular carcinoma". Oncology Reports 10 (2): 271–6. 2003. doi:10.3892/or.10.2.271. PMID 12579257.
- "Expression of 20alpha-hydroxysteroid dehydrogenase mRNA in human endometrium and decidua". Endocrine Journal 50 (1): 105–11. Feb 2003. doi:10.1507/endocrj.50.105. PMID 12733716.
- "Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids". Journal of Molecular Biology 331 (3): 593–604. Aug 2003. doi:10.1016/S0022-2836(03)00762-9. PMID 12899831.
- "Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes". Neurobiology of Disease 14 (1): 63–73. Oct 2003. doi:10.1016/S0969-9961(03)00101-3. PMID 13678667.
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