Biology:AKR1B10

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Aldo-keto reductase family 1 member B10 is an enzyme that in humans is encoded by the AKR1B10 gene.

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.

External links

• Human AKR1B10 genome location and AKR1B10 gene details page in the UCSC Genome Browser.
• Human ARL1 genome location and ARL1 gene details page in the UCSC Genome Browser.

Further reading

• "New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma". Hepatology 27 (4): 943–50. April 1998. doi:10.1002/hep.510270408. PMID 9537432. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899–903. December 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism". The Biochemical Journal 373 (Pt 3): 973–9. August 2003. doi:10.1042/BJ20021818. PMID 12732097. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research 14 (10B): 2121–7. October 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Aldose reductase (AC)n gene polymorphism and susceptibility to diabetic retinopathy in Type 2 diabetes in Caucasians". Journal of Diabetes and Its Complications 19 (2): 70–3. 2005. doi:10.1016/j.jdiacomp.2004.08.004. PMID 15745835. 
• "Phorbol ester up-regulates aldose reductase expression in A549 cells: a potential role for aldose reductase in cell cycle modulation". Cellular and Molecular Life Sciences 62 (10): 1146–55. May 2005. doi:10.1007/s00018-005-5024-4. PMID 15928807. 
• "Involvement of nuclear factor kappaB in up-regulation of aldose reductase gene expression by 12-O-tetradecanoylphorbol-13-acetate in HeLa cells". The International Journal of Biochemistry & Cell Biology 37 (11): 2297–309. November 2005. doi:10.1016/j.biocel.2005.04.016. PMID 15936242. 
• "Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice". The Journal of Clinical Investigation 115 (9): 2434–43. September 2005. doi:10.1172/JCI24819. PMID 16127462. 
• "High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase". Acta Crystallographica. Section D, Biological Crystallography 61 (Pt 10): 1413–7. October 2005. doi:10.1107/S0907444905024285. PMID 16204895. Bibcode: 2005AcCrD..61.1413H. 
• "[Transcription TIMP3, DAPk1 and AKR1B10 genes in squamous cell lung cancer]". Molekuliarnaia Biologiia 40 (6): 1047–54. 2007. doi:10.1134/s0026893306060148. PMID 17209433. 
• "Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells". Cancer Letters 252 (2): 299–306. July 2007. doi:10.1016/j.canlet.2007.01.001. PMID 17300864. 
• "Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention". International Journal of Cancer 121 (10): 2301–6. November 2007. doi:10.1002/ijc.22933. PMID 17597105. 

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Aldo-keto reductase family 1 member B10 (AKR1B10)]