Biology:Adipokine
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Short description: Type of cytokines secreted by adipose tissue
The adipokines, or adipocytokines (Greek adipo-, fat; cytos-, cell; and -kinos, movement) are cytokines (cell signaling proteins) secreted by adipose tissue. Some contribute to an obesity-related low-grade state of inflammation or to the development of metabolic syndrome, a constellation of diseases including, but not limited to, type 2 diabetes, cardiovascular disease and atherosclerosis.[1] The first adipokine to be discovered was leptin in 1994.[2] Since that time, hundreds of adipokines have been discovered.[3]
Members include:
- Leptin
- Adiponectin
- Apelin[4]
- chemerin[5]
- interleukin-6 (IL-6)[6]
- monocyte chemotactic protein-1 (MCP-1)[7]
- plasminogen activator inhibitor-1 (PAI-1)
- retinol binding protein 4 (RBP4)
- tumor necrosis factor-alpha (TNFα)[8]
- visfatin
- omentin
- vaspin (SERPINA12)
- progranulin
- CTRP-4
Interleukin 8 (IL-8), interleukin 10 (IL-10), interferon gamma (IFN-γ) and inducible protein 10 (IP-10 or CXCL10) have been shown to be associated with excessive body weight.[9]
See also
- Adipose tissue
- Hepatokines
- Myokines
Notes
- ↑ "The role of adipokines in chronic inflammation". ImmunoTargets and Therapy 5 (2016): 47–56. May 2016. doi:10.2147/ITT.S73223. PMID 27529061.
- ↑ "Adipokines: BioFactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity". BioFactors 37 (6): 413–420. 2011. doi:10.1002/biof.185. PMID 22038756.
- ↑ "Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders". Proteomics: Clinical Applications 6 (1–2): 91–101. 2012. doi:10.1002/prca.201100052. PMID 22213627.
- ↑ Guo L, Li Q, Wang W, Yu P, Pan H, Li P, Sun Y, Zhang J. Endocr Res. 2009;34(4):142-54.
- ↑ MacDougald1, Ormond A. and Burant, Charles F. (September 2007) "The Rapidly Expanding Family of Adipokines" Cell Metabolism 6: pp. 159-161
- ↑ Monzillo, Lais U. (2003) "Effect of Lifestyle Modification on Adipokine Levels in Obese Subjects with Insulin Resistance" Obesity Research 11(9): pp. 1048-1054
- ↑ Christiansen T., Richelsen B., and Bruun J.M. (2005) "Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects" International Journal of Obesity 29: pp. 146–150
- ↑ "Metabolic Messengers: tumour necrosis factor". Nature Metabolism 3 (10): 1302–1312. 2021. doi:10.1038/s42255-021-00470-z. PMID 34650277.
- ↑ Sharabiani, MT; Vermeulen R; Scoccianti C; Hosnijeh FS; Minelli L; Sacerdote C; Palli D; Krogh V et al. (May 2011). "Immunologic profile of excessive body weight". Biomarkers 16 (3): 243–51. doi:10.3109/1354750X.2010.547948. PMID 21506696.
External links
- Adipokines at the US National Library of Medicine Medical Subject Headings (MeSH)
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