Biology:Amanita ocreata

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Short description: Species of poisonous fungus in the genus Amanita

Amanita ocreata
Western North American destroying angel
Amanita ocreata 79782.jpg
Scientific classification edit
Domain: Eukaryota
Kingdom: Fungi
Division: Basidiomycota
Class: Agaricomycetes
Order: Agaricales
Family: Amanitaceae
Genus: Amanita
Species:
A. ocreata
Binomial name
Amanita ocreata
Peck
Amanita ocreata map.png
Approximate distribution (green)
Amanita ocreata
View the Mycomorphbox template that generates the following list
Mycological characteristics
gills on hymenium
cap is convex or flat
hymenium is free
stipe has a ring and volva
spore print is white
ecology is mycorrhizal
edibility: deadly

Amanita ocreata, commonly known as the death angel, destroying angel, angel of death or more precisely western North American destroying angel, is a deadly poisonous basidiomycete fungus, one of many in the genus Amanita. The large fruiting bodies (the mushrooms) generally appear in spring; the cap may be white or ochre and often develops a brownish centre, while the stipe, ring, gill and volva are all white. A. ocreata resemble several edible species commonly consumed by humans, increasing the risk of accidental poisoning. Mature fruiting bodies can be confused with the edible A. velosa (springtime amanita),[2] A. lanei or Volvopluteus gloiocephalus, while immature specimens may be difficult to distinguish from edible Agaricus mushrooms or puffballs.

The species occurs in the Pacific Northwest and California Floristic Provinces of North America, associating with oak trees. Similar in toxicity to the death cap (A. phalloides) and destroying angels of Europe (A. virosa) and eastern North America (A. bisporigera), it is a potentially deadly fungus responsible for several poisonings in California.[3] Its principal toxic constituent, α-Amanitin, damages the liver and kidneys, often fatally, and has no known antidote, though silybin and N-acetylcysteine show promise.[4] The initial symptoms are gastrointestinal and include abdominal pain, diarrhea and vomiting. These subside temporarily after 2–3 days, though ongoing damage to internal organs during this time is common; symptoms of jaundice, diarrhea, delirium, seizures, and coma may follow with death from liver failure 6–16 days post ingestion.

Taxonomy

Amanita ocreata was first described by American mycologist Charles Horton Peck in 1909 from material collected by Charles Fuller Baker in Claremont, California.[5] The specific epithet is derived from the Latin ocrěātus 'wearing greaves' from ocrea 'greave',[6] referring to its loose, baggy volva.[7] Amanita bivolvata is a botanical synonym. The mushroom belongs to the same section (Phalloideae) and genus (Amanita) as several deadly poisonous fungi including the death cap (A. phalloides) and several all-white species of Amanita known as "destroying angels": A. bisporigera of eastern North America, and the European A. virosa. "Death angel" is used as an alternate common name.

Description

Amanita ocreata is generally stouter than the other fungi termed destroying angels. It first appears as a white egg-shaped object covered with a universal veil. As it grows, the mushroom breaks free, though there may rarely be ragged patches of veil left at the cap edges. The cap is initially hemispherical, before becoming more convex and flattening, sometimes irregularly. This may result in undulations in the cap, which may be between 5–15 centimetres (2–6 inches) in diameter.[8] The colour varies from white, through yellowish-white to shades of ochre, sometimes with a brownish centre. Occasionally parts of the fruiting bodies may have pinkish tones. The rest of the fungus below the cap is white. The crowded gills are free to narrowly adnate. The stipe ranges from 6–20 cm (2 1⁄2–8 in) in height and is about 1–3 cm (1⁄2–1 1⁄4 in) thick, bearing a thin white membranous ring until old age.[8] The volva is thin, smooth and sac-like,[8] although may be quite extensive and contain almost half the stipe. The spore print is white, and the subglobose to ovoid to subellipsoid, amyloid spores are 9–14 x 7–10 μm viewed under a microscope.[3] There is typically no smell, though some fruiting bodies may have a slight odour, described as that of bleach or chlorine, dead fish or iodine. Like other destroying angels, the flesh stains yellow when treated with potassium hydroxide.[9][10]

Similar species

This fungus resembles the edible mushrooms Agaricus arvensis and A. campestris, and the puffballs (Lycoperdon spp.) before the caps have opened and the gills have become visible, so those collecting immature fungi run the risk of confusing the varieties. It also resembles and grows in the same areas as the edible and prized Amanita velosa, which can be distinguished from A. ocreata by its lack of ring, striate cap margin and thick universal veil remnants comprising the veil.[7] The edible Amanita calyptroderma lacks a ring and is more likely to have veil patches remaining on its cap, which is generally darker. Volvariella speciosa has pink spores and no ring or volva.[11]

Distribution and habitat

Appearing from January to April, A. ocreata occurs later in the year than other amanitas except A. calyptroderma. It is found in mixed woodland on the Pacific coast of North America,[3] from Washington (state) south through California to Baja California in Mexico.[10] It may feasibly occur on Vancouver Island in British Columbia though this has never been confirmed.[12] It forms ectomycorrhizal relationships and is found in association with coast live oak (Quercus agrifolia),[13] as well as hazel (Corylus spp.).[10] In Oregon and Washington, it may also be associated with the Garry oak (Quercus garryana).[12]

Toxicity

A. ocreata is highly toxic, and has been responsible for mushroom poisonings in western North America, particularly in the spring. It contains highly toxic amatoxins, as well as phallotoxins, a feature shared with the closely related death cap (A. phalloides), half a cap of which can be enough to kill a human, and other species known as destroying angels.[3][14] There is some evidence it may be the most toxic of all the North American phalloideae, as a higher proportion of people consuming it had organ damage and 40% perished.[15] Dogs have also been known to consume this fungus in California with fatal results.[16]

Amatoxins consist of at least eight compounds with a similar structure, that of eight amino-acid rings;[17] of those found in A. ocreata, α-Amanitin is the most prevalent and along with β-Amanitin is likely to be responsible for the toxic effects.[3][18][19] The major toxic mechanism is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). Without mRNA, essential protein synthesis and hence cell metabolism stop and the cell dies.[20] The liver is the principal organ affected, as it is the first organ encountered after absorption by the gastrointestinal tract, though other organs, especially the kidneys, are susceptible to the toxins.[21]

The phallotoxins consist of at least seven compounds, all of which have seven similar peptide rings. Although they are highly toxic to liver cells,[22] phallotoxins have since been found to have little input into the destroying angel's toxicity as they are not absorbed through the gut.[20] Furthermore, one phallotoxin, phalloidin, is also found in the edible (and sought-after) blusher (Amanita rubescens).[17]

Signs and symptoms

Signs and symptoms of poisoning by A. ocreata are initially gastrointestinal in nature and include colicky abdominal pain, with watery diarrhea and vomiting which may lead to dehydration and, in severe cases, hypotension, tachycardia, hypoglycemia, and acid-base disturbances.[23][24] The initial symptoms resolve two to three days after ingestion of the fungus. A more serious deterioration signifying liver involvement may then occur—jaundice, diarrhea, delirium, seizures, and coma due to fulminant liver failure and attendant hepatic encephalopathy caused by the accumulation of normally liver-removed substances in the blood.[25] Kidney failure (either secondary to severe hepatitis[26][27] or caused by direct toxic renal damage)[20] and coagulopathy may appear during this stage. Life-threatening complications include increased intracranial pressure, intracranial hemorrhage, sepsis, pancreatitis, acute kidney injury, and cardiac arrest.[23][24] Death generally occurs six to sixteen days after the poisoning.[28]

Treatment

Consumption of A. ocreata is a medical emergency that requires hospitalization. There are four main categories of therapy for poisoning: preliminary medical care, supportive measures, specific treatments, and liver transplantation.[4]

Preliminary care consists of gastric decontamination with either activated carbon or gastric lavage. However, due to the delay between ingestion and the first symptoms of poisoning, it is commonplace for patients to arrive for treatment long after ingestion, potentially reducing the efficacy of these interventions.[4][29] Supportive measures are directed towards treating the dehydration which results from fluid loss during the gastrointestinal phase of intoxication and correction of metabolic acidosis, hypoglycemia, electrolyte imbalances, and impaired coagulation.[4]

No definitive antidote for amatoxin poisoning is available, but some specific treatments such as intravenous penicillin G have been shown to improve survival.[30] There is some evidence that intravenous silibinin, an extract from the blessed milk thistle (Silybum marianum), may be beneficial in reducing the effects of amatoxins, preventing their uptake by hepatocytes, thereby protecting undamaged hepatic tissue.[31][32] In patients developing liver failure, a liver transplant is often the only option to prevent death. Liver transplants have become a well-established option in amatoxin poisoning.[33] This is a complicated issue, however, as transplants themselves may have significant complications and mortality; patients require long-term immunosuppression to maintain the transplant.[4] Evidence suggests that, although survival rates have improved with modern medical treatment, in patients with moderate to severe poisoning up to half of those who did recover suffered permanent liver damage.[34] However, a follow-up study has shown that most survivors recover completely without any sequelae if treated within 36 hours of mushroom ingestion.[35]

See also

References

  1. ↑ Siegel, N. (2021). "Amanita ocreata". IUCN Red List of Threatened Species 2021: e.T198477478A198489125. doi:10.2305/IUCN.UK.2021-2.RLTS.T198477478A198489125.en. https://www.iucnredlist.org/species/198477478/198489125. Retrieved 25 September 2021. 
  2. ↑ Arora, David (February 1, 1991). All That the Rain Promises and More: A Hip Pocket Guide to Western Mushrooms. ISBN 9780898153880. 
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Ammirati, Joseph F.; Thiers, Harry D.; Horgen, Paul A. (1977). "Amatoxin containing mushrooms:Amanita ocreata and Amanita phalloides in California". Mycologia (Mycologia, Vol. 69, No. 6) 69 (6): 1095–1108. doi:10.2307/3758932. PMID 564452. 
  4. ↑ 4.0 4.1 4.2 4.3 4.4 "Treatment of amatoxin poisoning: 20-year retrospective analysis". Journal of Toxicology: Clinical Toxicology 40 (6): 715–57. 2002. doi:10.1081/CLT-120014646. PMID 12475187. 
  5. ↑ Peck, Charles Horton (1909). "New species of fungi.". Bull. Torrey Bot. Club (Bulletin of the Torrey Botanical Club, Vol. 36, No. 6) 36 (6): 329–39. doi:10.2307/2479371. 
  6. ↑ Simpson, D.P. (1979). Cassell's Latin Dictionary (5 ed.). London: Cassell Ltd.. pp. 883. ISBN 978-0-304-52257-6. 
  7. ↑ 7.0 7.1 Arora, David (1986). Mushrooms demystified: a comprehensive guide to the fleshy fungi (2nd ed.). Berkeley: Ten Speed Press. pp. 271–73. ISBN 978-0-89815-169-5. https://archive.org/details/mushroomsdemysti00aror_0/page/271. 
  8. ↑ 8.0 8.1 8.2 Davis, R. Michael; Sommer, Robert; Menge, John A. (2012). Field Guide to Mushrooms of Western North America. Berkeley: University of California Press. pp. 74. ISBN 978-0-520-95360-4. OCLC 797915861. https://www.worldcat.org/oclc/797915861. 
  9. ↑ Thiers HD. (1982). The Agaricales (Gilled Fungi) of California 1: Amanitaceae. Eureka, CA: Mad River Press. ISBN:0-916422-24-0.
  10. ↑ 10.0 10.1 10.2 Tulloss, Rodham E.. "Amanita ocreata Peck "Western American Destroying Angel"". Studies in the Amanitaceae. http://www.amanitaceae.org/?Amanita+ochreata. 
  11. ↑ Wood, Michael; Fred Stevens (1998–2007). "California fungi:Amanita ocreata". The Fungi of California. http://www.mykoweb.com/CAF/species/Amanita_ocreata.html. 
  12. ↑ 12.0 12.1 Birch, Shannon (April 2006). "Is Amanita ocreata on Vancouver Island?". Fungifama: 5. http://www.svims.ca/ff0604.pdf. Retrieved 2007-12-11. 
  13. ↑ Benjamin, Mushrooms: poisons and panaceas, p. 205
  14. ↑ Benjamin, Mushrooms: poisons and panaceas p. 211
  15. ↑ Beug, Michael (April 2006). "Reflections on Mushroom Poisoning – Part I". Fungifama: 3–5. http://www.svims.ca/ff0604.pdf. Retrieved 2007-12-11. 
  16. ↑ Tegzes, John H.; Birgit Puschner (2002). "Amanita mushroom poisoning: efficacy of aggressive treatment of two dogs". Veterinary and Human Toxicology 44 (2): 96–99. PMID 11931514. 
  17. ↑ 17.0 17.1 Litten, Walter (March 1975). "The most poisonous mushrooms". Scientific American 232 (3): 90–101. doi:10.1038/scientificamerican0375-90. PMID 1114308. Bibcode: 1975SciAm.232c..90L. 
  18. ↑ Köppel, C. (1993). "Clinical symptomatology and management of mushroom poisoning". Toxicon 31 (12): 1513–40. doi:10.1016/0041-0101(93)90337-I. PMID 8146866. 
  19. ↑ Dart, Richard C. (2004). "Mushrooms". Medical toxicology. Philadelphia: Williams & Wilkins. pp. 1719–35. ISBN 978-0-7817-2845-4. 
  20. ↑ 20.0 20.1 20.2 Karlson-Stiber, Christine; Hans Persson (2003). "Cytotoxic fungi - an overview". Toxicon 42 (4): 339–49. doi:10.1016/S0041-0101(03)00238-1. PMID 14505933. 
  21. ↑ Benjamin, Mushrooms: poisons and panaceas, p. 217
  22. ↑ Wieland, Thomas; V.M. Govindan (1974). "Phallotoxins bind to actins". FEBS Letters 46 (1): 351–3. doi:10.1016/0014-5793(74)80404-7. PMID 4429639. 
  23. ↑ 23.0 23.1 Pinson CW (May 1990). "Liver transplantation for severe Amanita phalloides mushroom poisoning". American Journal of Surgery 159 (5): 493–9. doi:10.1016/S0002-9610(05)81254-1. PMID 2334013. 
  24. ↑ 24.0 24.1 "Amanita poisoning: Treatment and the role of liver transplantation". American Journal of Medicine 86 (2): 187–93. February 1989. doi:10.1016/0002-9343(89)90267-2. PMID 2643869. 
  25. ↑ North, Pamela Mildred (1967). Poisonous plants and fungi in colour. London: Blandford Press. OCLC 955264. 
  26. ↑ "Death cap mushroom poisoning". The New Zealand Medical Journal 108 (1001): 234. 1995. PMID 7603660. 
  27. ↑ Vetter, János (January 1998). "Toxins of Amanita phalloides". Toxicon 36 (1): 13–24. doi:10.1016/S0041-0101(97)00074-3. PMID 9604278. 
  28. ↑ "Histological criteria for diagnosis of Amanita phalloides poisoning". Journal of Forensic Sciences 41 (3): 429–32. 1996. doi:10.1520/JFS13929J. PMID 8656182. 
  29. ↑ "Therapy of cytotoxic mushroom intoxication". Critical Care Medicine 13 (5): 402–6. 1985. doi:10.1097/00003246-198505000-00007. PMID 3987318. 
  30. ↑ "Clinical death-cap (Amanita phalloides) poisoning: Prognostic factors and therapeutic measures" (in de). Schweizerische medizinische Wochenschrift 112 (34): 1164–1177. August 1982. PMID 6291147. 
  31. ↑ "Chemotherapy of Amanita phalloides poisoning with intravenous silibinin". Human Toxicology 2 (2): 183–95. 1983. doi:10.1177/096032718300200203. PMID 6862461. 
  32. ↑ Carducci R (1996). "Silibinin and acute poisoning with Amanita phalloides" (in it). Minerva Anestesiologica 62 (5): 187–93. PMID 8937042. 
  33. ↑ "Indication of liver transplantation following amatoxin intoxication". Journal of Hepatology 42 (2): 202–09. 2005. doi:10.1016/j.jhep.2004.10.023. PMID 15664245. 
  34. ↑ Benjamin, Mushrooms: poisons and panaceas, pp. 231–232
  35. ↑ "Amatoxin poisoning: A 15-year retrospective analysis and follow-up evaluation of 105 patients". Clinical Toxicology 45 (5): 539–42. 2007. doi:10.1080/15563650701365834. PMID 17503263. 

Works cited

  • Benjamin DR (1995). Mushrooms: poisons and panaceas — a handbook for naturalists, mycologists and physicians. New York, New York: WH Freeman and Company. ISBN 978-0-7167-2600-5. 

External links

Wikidata ☰ Q588770 entry



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